Mean platelet volume is associated with disease severity in patients with obstructive sleep apnea syndrome.
Mean platelet volume is associated with disease severity in patients with obstructive sleep apnea syndrome.
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DOI：
10.6061/clinics/2015(07)04
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发表时间：
2015-07
期刊：
影响因子：
--
通讯作者：
Çayli M
中科院分区：
文献类型：
--
作者：
Akyol S;Çörtük M;Baykan AO;Kiraz K;Börekçi A;Şeker T;Gür M;Çayli M
阻塞性睡眠呼吸暂停综合征与心血管疾病和血栓栓塞事件有关。平均血小板体积（MPV）是心血管血栓栓塞事件的预测因子。本研究的目的是探讨阻塞性睡眠呼吸暂停综合征患者的MPV与疾病严重程度之间的关系。我们前瞻性地纳入了194例无心血管疾病的阻塞性睡眠呼吸暂停综合征患者（平均年龄56.5±12.5岁），他们正在接受睡眠测试。对每例患者进行整夜完整的实验室polisomography检查。根据呼吸暂停低通气指数（AHI）将患者分为3组：（1）AHI低组：5≤AHI<15;（2）AHI低组：15<AHI≤30;（3）AHI高组：AHI>30。与其他组相比，AHI高组的MPV值最高（所有组p<0.05）。多元线性回归分析显示，MPV与AHI（β=0.500，p<0.001）和hs-CRP（β=0.194，p=0.010）相关。MPV与阻塞性睡眠呼吸暂停综合征患者的疾病严重程度和炎症独立相关。
Obstructive sleep apnea syndrome is associated with cardiovascular diseases and thromboembolic events. The mean platelet volume (MPV) is a predictor of cardiovascular thromboembolic events. The aim of the present study is to investigate the association between the MPV and disease severity in patients with obstructive sleep apnea syndrome. We prospectively included 194 obstructive sleep apnea syndrome patients without cardiovascular disease (mean age 56.5±12.5 years) who were undergoing sleep tests. An overnight full laboratory polisomnography examination was conducted on each patient. The patients were divided into 3 groups according to the apnea-hypopnea index (AHI): (1) AHIlow group: 5≤AHI<15, (2) AHImid group: 15<AHI≤30, and (3) AHIhigh group: AHI>30. The highest MPV values were found in the AHIhigh group compared with other groups (p<0.05 for all). Multiple linear regression analysis indicated that the MPV was associated with the AHI (β=0.500, p<0.001) and the high sensitivity C-reactive protein (hs-CRP) level (β=0.194, p=0.010). The MPV is independently associated with both disease severity and inflammation in patients with obstructive sleep apnea syndrome.
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影响因子：
5.3
作者：
Kaya, Mehmet Gungor;Yarlioglues, Mikail;Topsakal, Ramazan
通讯作者：
Topsakal, Ramazan
影响因子：
6.5
作者：
JAKUBOWSKI, JA;THOMPSON, CB;DEYKIN, D
通讯作者：
DEYKIN, D
影响因子：
158.5
作者：
YOUNG, T;PALTA, M;BADR, S
通讯作者：
BADR, S
影响因子：
6.7
作者：
Shitrit, D;Peled, N;Kramer, MR
通讯作者：
Kramer, MR
DOI：
10.3109/00365513.2010.520733
发表时间：
2010-11-01
影响因子：
2.1
作者：
Varol, Ercan;Ozturk, Onder;Akkaya, Ahmet
通讯作者：
Akkaya, Ahmet