Pulsed ultrasound differentially stimulates somatosensory circuits in humans as indicated by EEG and FMRI.
Pulsed ultrasound differentially stimulates somatosensory circuits in humans as indicated by EEG and FMRI.
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DOI：
10.1371/journal.pone.0051177
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Tyler WJ
中科院分区：
文献类型：
--
作者：
Legon W;Rowlands A;Opitz A;Sato TF;Tyler WJ
已知外周体感回路可对不同的刺激方式做出反应。能够引发体感反应的能量模式传统上属于机械、热、电磁和光子领域。据报道，应用于外周的超声波（美国）也会引起不同的躯体感觉。然而，这些观察结果主要基于主观报告，缺乏神经生理学描述。为了研究外周应用超声对人体体感脑回路活动的影响，我们使用脑电图记录了诱发电位，并对脉冲超声指尖刺激的血氧水平依赖性（BOLD）反应进行了功能磁共振成像。我们发现一种脉冲超声波形旨在引发轻微的振动感觉，能够可靠地触发具有不同波形形态（包括大双峰顶点电位）的诱发电位。用这种脉冲超声波形进行指尖刺激还会导致负责体感辨别的大脑区域（包括初级体感皮层和顶叶盖）以及参与分层体感处理的大脑区域（例如岛叶、前中扣带皮层和缘上回）出现 BOLD 信号。通过改变脉冲超声刺激波形的能量分布，我们观察到脉冲超声可以差异性地激活体感回路，并改变伴随诱发电位形态和 BOLD 反应模式变化的主观报告。基于这些观察，我们得出结论，脉冲超声可以在功能上刺激不同的体感纤维和受体，这可能为研究和诊断周围神经损伤、功能障碍和疾病提供新的方法。
Peripheral somatosensory circuits are known to respond to diverse stimulus modalities. The energy modalities capable of eliciting somatosensory responses traditionally belong to mechanical, thermal, electromagnetic, and photonic domains. Ultrasound (US) applied to the periphery has also been reported to evoke diverse somatosensations. These observations however have been based primarily on subjective reports and lack neurophysiological descriptions. To investigate the effects of peripherally applied US on human somatosensory brain circuit activity we recorded evoked potentials using electroencephalography and conducted functional magnetic resonance imaging of blood oxygen level-dependent (BOLD) responses to fingertip stimulation with pulsed US. We found a pulsed US waveform designed to elicit a mild vibration sensation reliably triggered evoked potentials having distinct waveform morphologies including a large double-peaked vertex potential. Fingertip stimulation with this pulsed US waveform also led to the appearance of BOLD signals in brain regions responsible for somatosensory discrimination including the primary somatosensory cortex and parietal operculum, as well as brain regions involved in hierarchical somatosensory processing, such as the insula, anterior middle cingulate cortex, and supramarginal gyrus. By changing the energy profile of the pulsed US stimulus waveform we observed pulsed US can differentially activate somatosensory circuits and alter subjective reports that are concomitant with changes in evoked potential morphology and BOLD response patterns. Based on these observations we conclude pulsed US can functionally stimulate different somatosensory fibers and receptors, which may permit new approaches to the study and diagnosis of peripheral nerve injury, dysfunction, and disease.
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DOI：
10.1016/j.cub.2011.12.010
发表时间：
2012-02-07
期刊：
Current biology : CB
影响因子：
--
作者：
Galkin VE;Orlova A;Egelman EH
通讯作者：
Egelman EH
影响因子：
3.7
作者：
Eickhoff, Simon B.;Grefkes, Christian;Fink, Gereon R.
通讯作者：
Fink, Gereon R.
影响因子：
7.4
作者：
Granovsky, Y;Matre, D;Casey, KL
通讯作者：
Casey, KL
影响因子：
5.7
作者：
Gelnar, PA;Krauss, BR;Apkarian, AV
通讯作者：
Apkarian, AV
影响因子：
8.6
作者：
Brotchie, Adam;Grieser, Franz;Ashokkumar, Muthupandian
通讯作者：
Ashokkumar, Muthupandian