Prairie voles as a novel model of socially facilitated excessive drinking.
Prairie voles as a novel model of socially facilitated excessive drinking.
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DOI：
10.1111/j.1369-1600.2010.00234.x
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发表时间：
2011-01
影响因子：
3.4
通讯作者：
Ryabinin AE
中科院分区：
文献类型：
--
作者：
Anacker AM;Loftis JM;Kaur S;Ryabinin AE
社会关系对人类饮酒有很大影响。传统的实验室啮齿动物不会表现出与特定同龄人的社会联系，也不能充分模拟这种关系是如何影响饮酒的。草原田鼠是一种社会性的一夫一妻制啮齿动物，用于研究社会纽带。这项研究测试了草原田鼠作为社会背景对饮酒影响的潜在模型。同性成年兄弟姐妹草原田鼠配对5天，然后要么分开放在单独的笼子里，要么成对饲养。从分离的时候开始，田鼠可以在两瓶水的选择测试中无限制地喝到酒精。与独居的田鼠相比，双居的兄弟姐妹表现出更高的酒精偏好，但不是糖精。两个人在一起时的饮酒量有显著相关性(r=0.79)，而分开时则没有相关性(r=0.20)。在自动分析指示黑暗阶段前后液体摄入量峰值的体液消耗昼夜节律模式后，建立了两个小时的有限访问两瓶选择程序。饮酒导致生理相关的血液乙醇浓度(BECs)和含有Urocortin的动眼周围神经元(但不在伏隔核或杏仁中央核)Fos免疫反应增强。草原田鼠对酒精的高度偏好和对社会操纵的敏感性表明，草原田鼠可以作为过度饮酒的社会影响的模范。
Social relationships strongly affect alcohol drinking in humans. Traditional laboratory rodents do not exhibit social affiliations with specific peers, and cannot adequately model how such relationships impact drinking. The prairie vole is a socially monogamous rodent used to study social bonds. The present study tested the prairie vole as a potential model for the effects of social affiliations on alcohol drinking. Same-sex adult sibling prairie voles were paired for five days, and then either separated into individual cages, or housed in pairs. Starting at the time of separation, the voles received unlimited access to alcohol in a two-bottle choice test versus water. Pair-housed siblings exhibited higher preference for alcohol, but not saccharin, than singly-housed voles. There was a significant correlation between the amount of alcohol consumed by each member of a pair when they were housed together (r = 0.79), but not when housed apart (r = 0.20). Following automated analysis of circadian patterns of fluid consumption indicating peak fluid intake before and after the dark phase, a limited access two-hour two-bottle choice procedure was established. Drinking in this procedure resulted in physiologically relevant blood ethanol concentrations (BECs) and increased Fos immunoreactivity in perioculomotor urocortin containing neurons (but not in nucleus accumbens or central nucleus of the amygdala). The high ethanol preference and sensitivity to social manipulation indicate that prairie voles can serve to model social influences on excessive drinking.
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影响因子：
2.9
作者：
Bachtell, RK;Wang, YM;Ryabinin, AE
通讯作者：
Ryabinin, AE
影响因子：
3.7
作者：
Grippo, Angela J.;Gerena, Davida;Carter, C. Sue
通讯作者：
Carter, C. Sue
影响因子：
5.3
作者：
Aragona, BJ;Liu, Y;Wang, ZX
通讯作者：
Wang, ZX
影响因子：
2.2
作者：
Douglas, LA;Varlinskaya, EI;Spear, LP
通讯作者：
Spear, LP
DOI：
10.1097/01.alc.0000183007.65998.aa
发表时间：
2005-10-01
影响因子：
3.2
作者：
Doremus, TL;Brunell, SC;Spear, LP
通讯作者：
Spear, LP