Body mass index, waist circumference, physical activity, and risk of hearing loss in women.
Body mass index, waist circumference, physical activity, and risk of hearing loss in women.
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DOI：
10.1016/j.amjmed.2013.04.026
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发表时间：
2013-12
影响因子：
5.9
通讯作者：
Curhan, Gary C.
中科院分区：
文献类型：
--
作者：
Curhan, Sharon G.;Eavey, Roland;Wang, Molin;Stampfer, Meir J.;Curhan, Gary C.
获得性听力损失非常普遍，但有关潜在可改变风险因素的前瞻性数据有限。在横断面研究中，较高的体重指数（BMI）、较大的腰围和较低的体力活动与较差的听力有关，但这些尚未得到前瞻性研究。我们检查了 1989 年至 2009 年护士健康研究 II 中 68,421 名女性的 BMI、腰围和体力活动以及自我报告的听力损失之间的独立关联。BMI、腰围和体力活动的基线和更新信息是从两年一次的问卷中获得的。经过超过 110 万人年的随访，据报告发生了 11,286 例听力损失病例。较高的体重指数和较大的腰围与听力损失的风险增加相关。与 BMI <25 kg/m2 的女性相比，BMI ≥ 40 的女性的多变量调整相对风险 (RR) 为 1.25 (95% CI 1.14,1.37)。与腰围 <71 cm 的女性相比，腰围 >88 cm 的多变量调整 RR 为 1.27 (95% CI 1.17, 1.38)。较高的体力活动与风险呈负相关；与体力活动最低五分位数的女性相比，最高五分位数女性的多变量调整 RR 为 0.83 (95% CI 0.78,0.88)。每周步行 2 小时或以上与风险呈负相关。同时调整体重指数、腰围和体力活动稍微减弱了这种关联，但仍具有统计学意义。较高的体重指数和较大的腰围与女性听力损失的风险增加相关，而较高的体力活动则与听力损失的风险降低相关。这些发现提供的证据表明，保持健康的体重和保持身体活跃以及潜在可改变的生活方式因素可能有助于降低听力损失的风险。
Acquired hearing loss is highly prevalent, but prospective data on potentially modifiable risk factors are limited. In cross-sectional studies, higher body mass index (BMI), larger waist circumference, and lower physical activity have been associated with poorer hearing, but these have not been examined prospectively. We examined the independent associations between BMI, waist circumference and physical activity and self-reported hearing loss in 68,421 women in the Nurses’ Health Study II from 1989 to 2009. Baseline and updated information on BMI, waist circumference and physical activity was obtained from biennial questionnaires. After more than 1.1 million person-years of follow-up, 11,286 cases of hearing loss were reported to have occurred. Higher BMI and larger waist circumference were associated with increased risk of hearing loss. Compared with women with BMI <25 kg/m2, the multivariate-adjusted relative risk (RR) for women with BMI ≥ 40 was 1.25 (95% CI 1.14,1.37). Compared with women with waist circumference <71 cm, the multivariate-adjusted RR for waist circumference >88 cm was 1.27 (95% CI 1.17, 1.38). Higher physical activity was inversely related to risk; compared with women in the lowest quintile of physical activity, the multivariate-adjusted RR for women in the highest quintile was 0.83 (95% CI 0.78,0.88). Walking 2 hours per week or more was inversely associated with risk. Simultaneous adjustment for BMI, waist circumference and physical activity slightly attenuated the associations but they remained statistically significant. Higher BMI and larger waist circumference are associated with increased risk and higher physical activity is associated with reduced risk of hearing loss in women. These findings provide evidence that maintaining healthy weight and staying physically active, potentially modifiable lifestyle factors, may help reduce the risk of hearing loss.
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影响因子：
39.2
作者：
Durga, Jane;Verhoef, Petra;Kok, Frans J.
通讯作者：
Kok, Frans J.
影响因子：
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Hasson, D.;Theorell, T.;Canlon, B.
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Canlon, B.
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Feskanich, D;Willett, W;Colditz, G
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Colditz, G
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作者：
Gielen, Stephan;Schuler, Gerhard;Adams, Volker
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Adams, Volker
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6.9
作者：
Hwang, Juen-Haur;Wu, Chen-Chi;Yang, Wei-Shiung
通讯作者：
Yang, Wei-Shiung