The pathology of social phobia is independent of developmental changes in face processing.
The pathology of social phobia is independent of developmental changes in face processing.
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DOI：
10.1176/appi.ajp.2011.10121740
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发表时间：
2011-11
期刊：
影响因子：
--
通讯作者：
Pine DS
中科院分区：
文献类型：
--
作者：
Blair KS;Geraci M;Korelitz K;Otero M;Towbin K;Ernst M;Leibenluft E;Blair RJ;Pine DS
虽然青春期的社交恐惧症(SP)预示着成年后SP的风险，但还没有研究直接比较SP成人和青少年的神经反应。本研究考察了成人和青少年SP对面部表情的神经反应，以确定成人SP在面孔加工过程中的神经关联是否也存在于青少年SP中。采用功能性磁共振成像(FMRI)对39例无药物治疗的SP患者(25例成人和14例青少年)和39例年龄、智商和性别匹配的健康对照组(23例成人和16例青少年)的血氧水平依赖(BOLD)进行了比较。在fMRI扫描中，个体在做出性别判断时看到愤怒、恐惧和中性的表情刺激。在杏仁核和嘴前扣带回皮质(RACC)观察到显著的情绪诊断交互作用。在这些地区，青少年和成年SP患者都表现出明显的大胆反应，相对于他们各自年龄匹配的对照组，没有证据表明年龄相关的调节组间差异。这些增强的反应特别发生在愤怒(RACC)和恐惧(杏仁核和rACC)，但不是中性的表情。此外，在成人中，SP的严重程度与这种增强的rACC反应显著相关。成人P物质在面孔加工过程中的神经联系也在青少年中表现出来。因此，在成人SP中观察到的神经关联可能代表了在生命早期建立的轮廓的持久性，而不是对这种早期扰动或成熟变化的适应性反应。这些横断面观察可能会鼓励对青少年SP进行纵向fMRI研究。
While social phobia (SP) in adolescence predicts risk for SP in adulthood, no work has directly compared neural responses in SP adults and adolescents. The current study examines neural response to facial expressions in adult and adolescent SP to determine whether the neural correlates of adult SP during face processing also manifest in adolescent SP. Blood oxygen level-dependent (BOLD) was compared in 39 medication-free individuals with SP (25 adults and 14 adolescents), and 39 healthy comparison individuals (23 adult and 16 adolescent) matched on age, IQ, and gender using functional magnetic resonance imaging (fMRI). During fMRI scans, individuals saw angry, fearful, and neutral expression stimuli while making a gender judgment. Hypothesized significant diagnosis-by-emotion interactions were observed within the amygdala and rostral anterior cingulate cortex (rACC). In these regions, the adolescent and adult SP patients both showed significantly increased BOLD responses, relative to their respective age-matched comparison groups, with no evidence of age-related modulation of between-group differences. These enhanced responses occurred specifically to angry (rACC) and fearful (amygdala and rACC) but not neutral expressions. In addition, SP severity correlated significantly with this enhanced rACC response in the adults. The neural correlates of adult SP during face processing also manifest in adolescents. As such, neural correlates observed in adult SP may represent the persistence of profiles established earlier in life, rather than adaptive responses to such earlier perturbations or maturational changes. These cross-sectional observations might encourage longitudinal fMRI studies of adolescent SP.
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影响因子：
--
作者：
Guyer, Amanda E.;Lau, Jennifer Y. F.;McClure-Tone, Erin B.;Parrish, Jessica;Shiffrin, Nina D.;Reynolds, Richard C.;Chen, Gang;Blair, R. J. R.;Leibenluft, Ellen;Fox, Nathan A.;Ernst, Monique;Pine, Daniel S.;Nelson, Eric E.
通讯作者：
Nelson, Eric E.
影响因子：
--
作者：
Beesdo, Katja;Lau, Jennifer Y. F.;Guyer, Amanda E.;McClure-Tone, Erin B.;Monk, Christopher S.;Nelson, Eric E.;Fromm, Stephen J.;Goldwin, Michelle A.;Wittchen, Hans-Ulrich;Leibenluft, Ellen;Erns, Monique;Pine, Daniel S.
通讯作者：
Pine, Daniel S.
影响因子：
17.7
作者：
Monk, Christopher S.;Nelson, Eric E.;Pine, Daniel S.
通讯作者：
Pine, Daniel S.
影响因子：
17.7
作者：
Marsh, Abigail A.;Finger, Elizabeth C.;Blair, R. J. R.
通讯作者：
Blair, R. J. R.
DOI：
10.1176/appi.ajp.2010.09121797
发表时间：
2010-12
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Blair KS;Geraci M;Hollon N;Otero M;DeVido J;Majestic C;Jacobs M;Blair RJ;Pine DS
通讯作者：
Pine DS