Detection of two porcine circovirus type 2 genotypic groups in United States swine herds.
Detection of two porcine circovirus type 2 genotypic groups in United States swine herds.
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DOI：
10.1007/s00705-006-0909-6
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发表时间：
2007
影响因子：
2.7
通讯作者：
Dunham AG
中科院分区：
文献类型：
--
作者：
Cheung AK;Lager KM;Kohutyuk OI;Vincent AL;Henry SC;Baker RB;Rowland RR;Dunham AG
在2005年底，在美国的几个猪群中，在10至16周龄的生长猪中观察到了一种高死亡率的急性发病疾病的零星病例。对来自堪萨斯、爱荷华州和北卡罗来纳州的受影响猪的组织进行了检查，在这些组织中一致地检测到猪圆环病毒2型（PCV 2）。系统发生学上，PCV 2可分为两个主要基因型组，PCV 2-组1和PCV 2-组2。尽管在所有患病动物中均检出PCV 2-组1分离株，但仅两只患病动物携带PCV 2-组2分离株。这一观察结果很重要，因为之前从未在美国报告过PCV 2 - 1组分离株（GenBank截至2006年5月16日），并且它们与之前在欧洲和亚洲描述的PCV 2 - 1组分离株密切相关。我们的分析表明，每个基因型组包含一个独特的延伸的核苷酸或氨基酸序列，可以作为一个签名基序的PCV 2-组1或PCV 2-组2分离株。
In late 2005, sporadic cases of an acute onset disease of high mortality were observed in 10- to 16-week-old growing pigs among several swine herds of the United States. Tissues from the affected pigs in Kansas, Iowa, and North Carolina were examined, and porcine circovirus type 2 (PCV2) was detected consistently among these tissues. Phylogenetically, PCV2 can be divided into two major genotypic groups, PCV2-group 1 and PCV2-group 2. Whereas PCV2-group 1 isolates were detected in all the diseased animals, only two of the diseased animals harbored PCV2-group 2 isolates. This observation is important because PCV2-group 1 isolates had never been reported in the United States before (GenBank as of May 16, 2006), and they are closely related to the PCV2-group 1 isolates that have been described in Europe and Asia, previously. Our analysis revealed that each genotypic group contains a distinct stretch of nucleotide or amino acid sequence that may serve as a signature motif for PCV2-group 1 or PCV2-group 2 isolates.
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影响因子：
3.8
作者：
Meehan, BM;McNeilly, F;Allan, GM
通讯作者：
Allan, GM
影响因子：
2.5
作者：
Segales, Joaquim;Allan, Gordon M.;Domingo, Mariano
通讯作者：
Domingo, Mariano
影响因子：
3.7
作者：
Cheung, AK
通讯作者：
Cheung, AK
影响因子：
3.3
作者：
Mankertz, A;Çaliskan, R;Finsterbusch, T
通讯作者：
Finsterbusch, T
影响因子：
64.8
作者：
TISCHER, I;GELDERBLOM, H;KOCH, MA
通讯作者：
KOCH, MA