Simultaneous multi-slice Turbo-FLASH imaging with CAIPIRINHA for whole brain distortion-free pseudo-continuous arterial spin labeling at 3 and 7 T.
Simultaneous multi-slice Turbo-FLASH imaging with CAIPIRINHA for whole brain distortion-free pseudo-continuous arterial spin labeling at 3 and 7 T.
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DOI：
10.1016/j.neuroimage.2015.03.060
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发表时间：
2015-06
期刊：
影响因子：
5.7
通讯作者：
Wang DJ
中科院分区：
文献类型：
--
作者：
Wang Y;Moeller S;Li X;Vu AT;Krasileva K;Ugurbil K;Yacoub E;Wang DJ
最近尝试将同步多切片 (SMS) 或多波段 (MB) 成像与回波平面成像 (EPI) 读出结合用于动脉自旋标记 (ASL) 灌注 MRI。研究发现，SMS-EPI 可以降低标签的 T1 弛豫效应，提高图像覆盖范围和分辨率，同时对信噪比 (SNR) 影响很小。然而，EPI 仍然遭受场不均匀效应造成的几何失真和信号丢失，特别是在高和超高磁场下。在这里，我们提出了一种新颖的方案，通过将伪连续 ASL (pCASL) 与 SMS Turbo-FLASH (TFL) 读数相结合，在 3 和 7 特斯拉下实现高保真无失真定量灌注成像。进行布洛赫方程模拟来表征和优化基于 TFL 的 pCASL 灌注信号。在 SMS-TFL pCASL 中实施两个 MB 因子（3 和 5），并与标准 2D TFL 和 EPI pCASL 序列进行比较。对于MB因子3和5，SMS-TFL pCASL相对于标准TFL pCASL的时间SNR在7T时分别为0.76±0.10和0.74±0.11，在3T时为0.70±0.05和0.65±0.05。通过在 3T 下结合 SMS-TFL 实施背景抑制，MB 因子为 3 和 5 时，相对时间 SNR 分别提高到 0.84±0.09 和 0.79±0.10。与 EPI pCASL 相比，使用 SMS-TFL pCASL 显着提高了时间 SNR (p<0.001) 并改善了眶额皮质的可视化。通过将 SMS 加速与 TFL pCASL 相结合，我们证明了高磁场和超高磁场下全脑无失真脑血流定量绘图的可行性。
Simultaneous multi-slice (SMS) or multiband (MB) imaging has recently been attempted for arterial spin labeled (ASL) perfusion MRI in conjunction with echo-planar imaging (EPI) readout. It was found that SMS-EPI can reduce the T1 relaxation effect of the label, improve image coverage and resolution with little penalty in signal-to-noise ratio (SNR). However, EPI still suffers from geometric distortion and signal dropout from field inhomogeneity effects especially at high and ultrahigh magnetic fields. Here we present a novel scheme for achieving high fidelity distortion-free quantitative perfusion imaging by combining pseudo-continuous ASL (pCASL) with SMS Turbo-FLASH (TFL) readout at both 3 and 7 Tesla. Bloch equation simulation was performed to characterize and optimize the TFL-based pCASL perfusion signal. Two MB factors (3 and 5) were implemented in SMS-TFL pCASL and compared with standard 2D TFL and EPI pCASL sequences. The temporal SNR of SMS-TFL pCASL relative to that of standard TFL pCASL was 0.76±0.10 and 0.74±0.11 at 7T, 0.70±0.05 and 0.65±0.05 at 3T for MB factor of 3 and 5, respectively. By implementing background suppression in conjunction with SMS-TFL at 3T, the relative temporal SNR improved to 0.84±0.09 and 0.79±0.10 for MB factor of 3 and 5 respectively. Compared to EPI pCASL, significantly increased temporal SNR (p<0.001) and improved visualization of orbitofrontal cortex were achieved using SMS-TFL pCASL. By combining SMS acceleration with TFL pCASL, we demonstrated the feasibility for whole brain distortion-free quantitative mapping of cerebral blood flow at high and ultrahigh magnetic fields.
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影响因子：
5.7
作者：
Sotiropoulos, Stamatios N.;Jbabdi, Saad;Xu, Junqian;Andersson, Jesper L.;Moeller, Steen;Auerbach, Edward J.;Glasser, Matthew F.;Hernandez, Moises;Sapiro, Guillermo;Jenkinson, Mark;Feinberg, David A.;Yacoub, Essa;Lenglet, Christophe;Van Essen, David C.;Ugurbil, Kamil;Behrens, Timothy E. J.
通讯作者：
Behrens, Timothy E. J.
影响因子：
7.6
作者：
Borogovac A;Asllani I
通讯作者：
Asllani I
影响因子：
4.8
作者：
Detre, John A.;Wang, Jiongjiong;Rao, Hengyi
通讯作者：
Rao, Hengyi
影响因子：
3.3
作者：
Feinberg, David A.;Beckett, Alexander;Chen, Liyong
通讯作者：
Chen, Liyong
影响因子：
5.7
作者：
Van Essen, D. C.;Ugurbil, K.;Auerbach, E.;Barch, D.;Behrens, T. E. J.;Bucholz, R.;Chang, A.;Chen, L.;Corbetta, M.;Curtiss, S. W.;Della Penna, S.;Feinberg, D.;Glasser, M. F.;Harel, N.;Heath, A. C.;Larson-Prior, L.;Marcus, D.;Michalareas, G.;Moeller, S.;Oostenveld, R.;Petersen, S. E.;Prior, F.;Schlaggar, B. L.;Smith, S. M.;Snyder, A. Z.;Xu, J.;Yacoub, E.
通讯作者：
Yacoub, E.