Sensory input is required for callosal axon targeting in the somatosensory cortex.
Sensory input is required for callosal axon targeting in the somatosensory cortex.
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体感皮层的胼胝体轴突定位需要感觉输入
DOI：
10.1186/1756-6606-6-53
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发表时间：
2013-12-05
期刊：
影响因子：
3.6
通讯作者：
Ding YQ
中科院分区：
文献类型：
--
作者：
Huang Y;Song NN;Lan W;Zhang Q;Zhang L;Zhang L;Hu L;Chen JY;Zhao CJ;Li L;Xu L;Ding YQ
背景感觉输入通常被认为对于大脑发育过程中细化和巩固神经元连接是必要的。我们在这里报告，体感皮层中的皮质胼胝轴突需要感觉输入来选择对侧皮层中的目标。结果通过单侧横断眶下神经（ION）消除任一半球的感觉输入可以防止对侧皮层中胼胝轴突的目标选择。引人注目的是，通过同时横断两个 ION 来阻断双侧感觉输入，可以挽救胼胝体投射。相反，非同时双侧 ION 横断与单侧 ION 横断具有相同的效果。通过胡须毛囊的损伤也获得了类似的结果。在单侧去除感觉输入的情况下，用 KCl 处理的脑切片中的 c-Fos 阳性神经元在对侧皮层中减少更多，但在同时双边去除感觉输入的小鼠中，两侧皮层中的 c-Fos 阳性神经元的减少程度相似。随着单侧感觉输入的去除，对侧皮质神经元的 sEPSC 频率也会降低，但随着双侧感觉输入的去除，两侧皮质神经元的 sEPSC 频率同样降低，这表明不平衡的双侧感觉输入可能导致两个皮质之间的神经元活动不匹配，并有助于胼胝体投射的形成。结论我们的数据证明了平衡的关键作用 双侧体感输入在胼胝体连接形成中的作用，从而揭示了感觉输入在脑回路连接中的新作用。
BackgroundSensory input is generally thought to be necessary for refining and consolidating neuronal connections during brain development. We here report that cortical callosal axons in somatosensory cortex require sensory input for their target selection in contralateral cortex.ResultsEliminating sensory input to either hemisphere by unilateral transection of infraorbital nerve (ION) prevents target selection of callosal axons in contralateral cortex. Strikingly, blocking sensory input bilaterally, by simultaneously transecting both IONs, results in rescued callosal projection. In contrast, non-simultaneous bilateral ION transection has the same effect as unilateral transection. Similar results are obtained by lesion of whisker hair follicles. c-Fos-positive neurons in brain slices treated with KCl is decreased more in contralateral cortex with unilateral removal of sensory input, but decreased similarly in both cortices in mice with simultaneous bilateral removal of sensory input. Frequency of sEPSC of cortical neurons is also reduced in contralateral cortex with the unilateral removal of sensory input, but equally reduced on both sides with the bilateral removal of sensory input, suggesting that unbalanced bilateral sensory input might lead to mismatched neuronal activity between the two cortices and contribute to the formation of callosal projection.ConclusionOur data demonstrate a critical role of balanced bilateral somatosensory input in the formation of callosal connections, and thus reveal a new role of sensory input in wiring brain circuits.
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影响因子：
2.5
作者：
RICE, FL;VANDERLOOS, H
通讯作者：
VANDERLOOS, H
DOI：
10.1073/pnas.87.4.1396
发表时间：
1990-02-01
影响因子：
11.1
作者：
KORALEK, KA;KILLACKEY, HP
通讯作者：
KILLACKEY, HP
影响因子：
16.2
作者：
Frenkel, MY;Bear, MF
通讯作者：
Bear, MF
影响因子：
2.7
作者：
Qiu, MS;Anderson, S;Rubenstein, JLR
通讯作者：
Rubenstein, JLR
影响因子：
56.9
作者：
Catalano, SM;Shatz, CJ
通讯作者：
Shatz, CJ