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Cell biology of an evolutionarily conserved ciliary compartment essential for cellular signalling

Cell biology of an evolutionarily conserved ciliary compartment essential for cellular signalling
对细胞信号转导至关重要的进化保守的睫状室的细胞生物学
批准号:
321731
负责人:
Leroux Michel R
金额:
$50.27万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2015
资助国家:
加拿大
项目状态:
已结题
起止时间:
2015-03-01 至 2020-03-01

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中文摘要
翻译
纤毛是细胞的“天线”,使许多重要的生理和发育过程得以实现。例如,活动的纤毛清除呼吸道的碎片,使精子运动。感觉(非运动)纤毛从大多数器官和器官的细胞中突出
英文摘要
Cilia are cellular 'antenna' that enable many essential physiological and developmental processes. For example, motile cilia clear respiratory airways of debris and allow sperm movement. Sensory (non-motile) cilia protrude from the cells of most organs an
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Regulation of the intraflagellar transport pathway, a mutational hotspot required for cilium formation and maintenance
Functional genomics of cilium formation and maintenance
Dissecting the molecular and cellular links between cilia, cGMP signaling, physiology and disease
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