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Mechanisms linking reduced circulating insulin to insulin sensitivity and longevity

Mechanisms linking reduced circulating insulin to insulin sensitivity and longevity
将循环胰岛素减少与胰岛素敏感性和寿命联系起来的机制
批准号:
408012
负责人:
Johnson James D
金额:
$79.42万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2019
资助国家:
加拿大
项目状态:
已结题
起止时间:
2019-09-01 至 2024-09-01

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中文摘要
翻译
先天和后天都有助于我们新陈代谢和储存食物,以及健康的衰老。在之前的CIHR资助中,我们第一次表明,适度减少胰岛素分泌可以延长哺乳动物的寿命。我们还表明,减少过剩的
英文摘要
Nature and nurture both contribute to how we metabolize and store food, and healthy aging. With previous CIHR funding we showed for the first time that a modest reduction in insulin secretion extends lifespan mammals. We also showed that reducing excess i
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  • 批准号:
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  • 资助金额:
    $7.29万
  • 财政年份:
    2022
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Beta-cell resilience to insulin-driven stress in type 1 diabetes: Lessons from both sexes
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Mechanisms by which hyperinsulinemia promotes pancreatic cancer
  • 批准号:
    408005
  • 项目类别:
    Operating Grants
  • 资助金额:
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  • 财政年份:
    2019
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  • 依托单位:
Regulation of beta-cell proliferation by insulin production workload
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海外基金