Acquisition of an X-ray Diffractometer and Area Detector

将获得X射线衍射仪和面积检测器。 一 各种各样的生物项目将得到新的支持， 设备. 将得到支持的项目还包括 对一种疏水性植物蛋白- 来自小麦的溶血毒素; kringle 4，一种酶的片段 纤溶酶原;藻蓝蛋白，一种捕光天线细菌 蛋白质;和突变型天冬氨酸转氨甲酰酶，一种酶 在嘧啶代谢中重要;天然产物;合成 有机分子的受体;金属离子与核酸的络合物 酸;与辅酶结合的金属离子。 这些晶体学 对小分子和其他大分子的研究将是 结合许多其他技术，如CD、拉曼、NMR 和ESR光谱;平衡结合测定和酶 动力学;有机合成;计算机图形与分子 力学和结构预测。 总的来说，其目的是 来研究结构与功能的关系， 结构信息与动态信息相结合， 对大分子功能的全面了解。 的 晶体结构测定也将作为一种 天然产物有机合成的重要辅助手段， 合成受体的设计

An x-ray diffractometer and area detector will be acquired. A wide variety of biological projects will be supported by the new equipment. Among the projects to be supported are further studies on crambin, a hydrophobic plant protein; purothionin, a hemolytic toxin from wheat; kringle 4, a fragment of the enzyme plasminogen; phycocyanin, a light harvesting antenna bacterial protein; and mutant aspartate transcarbamylases, an enzyme important in pyrimidine metabolism; natural products; synthetic receptors for organic molecules; metal ion complexes with nucleic acids; metal ions bound to coenzymes. These crystallographic studies on small molecules and other macromolecules will be combined with numerous other techniques such as CD, Raman, NMR and ESR spectroscopy; equilibrium binding assays and enzymatic kinetics; organic synthesis; computer graphics and molecular mechanics and structural prediction. On the whole, the intent is to look at structure-function relationships, integrating static structural information with dynamic information to gain a more complete understanding of macromolecular function. The crystallographic structural determination will also serve as an important adjunct to organic synthesis of natural products and to the design of synthetic receptors.