Electrochemical Amination Reactions for Amino Acid Synthesis

这一奋进的目的是发展一个有效的 用于商业生产氨基的电化学方法 acids. PI计划使用电化学产生的 均相催化剂以制备DL-多巴和DL-苯丙氨酸。 这些产品分别用于制备 人工甜味剂Nutrasweet和治疗 帕金森氏症。 计划中的实验项目旨在获得 深入了解参与的电化学反应机制， 氨基酸合成 电化学过程可以具有 具有以下优点：（1）提供了比常规方法更高的选择性， 等效的化学过程;（2）对环境更友好; （3）提供一个简化的整体的机会 一个或多个步骤通常存在于 可以避免常规的化学方法。 这个项目 还可以增加对电解槽的全面了解。 PI在电化学和公司方面拥有丰富的经验 有设备来执行提议的工作。 为此提供资金 建议第一阶段。

The purpose of this endeavor is to develop an efficient electrochemical process for the commercial production of amino acids. The PI plans to use electrochemically generated homogeneous catalysts to produce dl-dopa and dl-phenylalanine. These products are used respectively in the preparation of the artificial sweetener Nutrasweet and in the treatment of Parkinson's disease. The experimental program planned is directed towards gaining insight into electrochemical reaction mechanisms involved in the amino acid sythesis. Electrochemical processes may possess the following advantages: (1) provide greater selectivity than an equivalent chemical process; (2) be environmentally more benign; and (3) provide the opportunity for a simplified overall industrial process where one or more steps normally found in conventional chemical processes can be avoided. This project could also increase overall understnading of electrolytic cells. The PI has broad experience in electrochemistry and the company has the equipment to perform the proposed work. Funding of this Phase I is recommended.