U.S.-Hungary Biochemical Research on Structurally Related Serine Proteases

美国的主要目标是-匈牙利合作研究 加州大学的威廉·鲁特博士 旧金山弗朗西斯科和布达佩斯埃奥特沃斯大学的拉斯洛·格拉夫博士， 是研究丝氨酸蛋白酶（酶）的催化机制， 从而解决与蛋白质结构相关的未解决的问题 这些酶的作用。 其目的是辨别 丝氨酸蛋白酶的基本分子特征， 了解基板结构基础的关键方面 的特异性 结果应该会产生一个很好的测试用例 定点突变在蛋白质分子中的应用 工程. 生物化学的这个项目实现了 促进科学知识的发展， 美国和东欧联合收割机互补的人才， 集中资源，共享研究设施， 共同利益和能力。

The primary objective of this U.S.-Hungary cooperative research project between Dr. William Rutter of the University of California, San Francisco , and Dr. Laszlo Graf of Eotvos University, Budapest, is to study the catalytic mechanisms of serine proteases (enzymes) and thereby address unsolved issues related to protein structure and action of these enzymes. The intent is to discern the fundamental molecular features of serine proteases in order to understand key aspects of the structural basis of substrate specificity. Results should yield a good test case for the application of site-directed mutagenesis in protein molecule engineering. This project in biochemistry fulfills the program objective of advancing scientific knowledge by enabling leading experts in the United States and Eastern Europe to combine complementary talents, pool resources and share research facilities in areas of strong mutual interests and competence.