Acquisition of a 250 MHz FT NMR Spectrometer

核磁共振波谱是化学家用来阐明分子结构的最有力的工具。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱是必不可少的。俄勒冈州立大学化学系将利用化学共享仪器计划和生物仪器计划的奖励来帮助购买250 MHz傅立叶变换核磁共振波谱仪。收购该仪器将促进化学和生物学领域的发展，包括：1)抗生素的生物有机研究2)天然产物和合成中间体的核磁共振结构分析3)核磁共振在寡核苷酸类似物和吗啡生物碱合成中的应用4)海洋植物生物医学相关天然产物的结构鉴定5)吡咯里西丁生物碱代谢产物对DNA的烷基化作用6)DNA结构和相互作用的生物物理研究：核磁共振技术的应用

Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to the chemist for the elucidation of the structure of molecules. It is used to identify unknown substances, characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solutions. Access to state-of-the-art NMR spectrometry is essential to chemists who are carrying out frontier research. The Department of Chemistry of Oregon State University will use an award from the Chemistry Shared Instrumentation Program and the Biological Instrumentation Program to help purchase 250 MHz Fourier Transform NMR spectrometer. The areas of chemistry and biology that will be enhanced by the acquisition of the instrument include: 1) Bioorganic Studies of Antibiotics 2) Structural Analysis of Natural Products and Synthetic Intermediates by NMR 3) The use of NMR in the Synthesis of Oligonucleotide Analogs and the Morphine Alkaloids 4) Structure Elucidation of Biomedically Relevant Natural Products from Marine Plants 5) Alkylation of DNA by Pyrrolizidine Alkaloid Metabolites 6) Biophysical Studies on DNA Structures and Interactions: Application of NMR Techniques