Desorption Ionization Studies Using Fourier Transform Mass Spectrometry

这个项目是在一般地区的分析和表面 化学和在气相反应和质量的子领域 光谱法这项研究的重点是开发方法 用于大生物分子的结构表征， 研究离子捕获和离子检测的基本原理， 傅里叶变换离子回旋共振（FT-ICR）。大 本项目的重点将放在理解 光解离后肽的解离反应，或 与有机碱金属离子反应。具体研究内容 建议检查影响ICR信号的因素 使用FT-ICR分析的各种物种。 这项研究旨在更好地了解 生物分子在分离后会在气相中分解 相对高能量的光子或与碱的反应 金属离子种类。这项研究的最终目的是 提供更好的表征高 分子量生物分子。

This project is in the general area of analytical and surface chemistry and in the subfields of gas phase reactions and mass spectrometry. The focus of this research is to develop methods for structural characterization of large biomolecules and to study the fundamentals of ion trapping and ion detection using Fourier transform ion cyclotron resonance (FT-ICR). A large emphasis of this project will be placed on understanding dissociation reactions of peptides after photodissociation or reaction with organo-alkali metal ions. Specific studies are proposed to examine the factors which influence the ICR signal of various species which are analyzed using FT-ICR. This research is designed to better understand how large biomolecules will break apart in the gas phase after absortion of relatively high energy photons or reactions with alkali metal ion species. The ultimate goal of this research is to provide better capabilities for characterization of high molecular weight biomolecules.