RUI: Acquisition of an FT-NMR Spectrometer

这是一项获得一台配备变温1H/13C探头和变温控制器的300 MHz核磁共振波谱仪的建议。该仪器将作为化学系成员在以下领域的主要研究工具：1.具有生物意义的天然产物的分离、结构验证和合成。2.钙调素-多肽相互作用的核磁共振研究3.疏水相互作用的热力学研究这些研究工作需要高灵敏度和分辨率以及可变的温度控制。这项仪器的购置预计将对该部的研究工作产生重大的积极影响。该仪器的使用将使每年有5-10名本科生参加高级研究，并有类似数量的本科生参加夏季研究。

This is a proposal to obtain a 300 MHz nuclear magnetic resonance spectrometer equipped with variable temperature 1H/13C probe and a variable temperature controller. The instrument will serve as a major research tool by members of the chemistry department in the following areas: 1. isolation, structure proof and synthesis of biologically significant natural products. 2. NMR studies of calmodulin - peptide interactions 3. thermodynamic study of the hydrophobic interaction These research efforts require high sensitivity and resolution plus variable temperature control. Acquisition of this instrument is expected to have a dramatic, positive effect on the research efforts of the Department. The utilization of the instrument will involve 5-10 undergraduates a year in senior research and similar number in summer research.