Displacement Chromatography on Cyclodextrin Silicas

这项研究是在一般领域的分析和表面 化学和色谱的子领域。 方法将 开发允许分离化合物称为 对映异构体，目前非常难以纯化， 现有程序。 本研究的目的是建立一个制备 通过展开分离对映体化合物的方法 用于置换的环糊精改性二氧化硅 色谱程序。 这将解决重要的 纯手性药物制备中的药学问题 有望用作抗炎剂的化合物， β受体阻滞剂、血小板活化因子和抗溃疡药物。

This research is in the general area of analytical and surface chemistry and in the subfield of chromatography. Methods will be developed that permit the separation of compounds called enantiomers that are presently very difficult to purify by existing procedures. The objectives of this research are to establish preparative methods for separating enantiomeric compounds by developing cyclodextrin modified silicas for use in displacement chromatographic procedures. This would solve important pharmaceutical problems in the preparation of pure chiral compounds that hold promise for use as anti-inflammatory, beta-blocker, platelet activating factor and anti-ulcer drugs.