How the brain learns and uses inhibitory predictions.

人类和其他动物很容易学会预测重要事件缺失的线索和行为。然而，在哺乳动物的大脑中，这种抑制预测是如何以及在哪里被处理的仍不清楚。该项目旨在证明抑制预测通常是在内侧前额叶皮层编码和检索的，而没有任何关于缺失事件的详细信息。它结合了一种独特的行为方法和操纵行为啮齿类动物大脑活动的最新工具。该项目希望对哺乳动物大脑如何从环境中提取抑制预测，以最优方式指导我们的行为和决策产生新的见解。

Humans and other animals readily learn about cues and actions that predict the absence of important events. Yet, how and where such inhibitory predictions are processed in the mammalian brain remains unclear. This project aims to demonstrate that inhibitory predictions are generally encoded and retrieved in the medial prefrontal cortex, without any detailed information about the absent events. It combines a unique behavioural approach with the latest tools for manipulation of brain activity in behaving rodents. The project expects to generate new insights into how the mammalian brain extracts inhibitory predictions from the environment to guide our behaviours and decisions in the most optimal way.