New Reactions for Organic Synthesis

这项研究由有机合成计划资助。 奥弗曼博士将继续开发新的成环技术 反应，特别是集中在中环范围。 这将提供一些新的工具， 农业和工业日益复杂的需求。 本项目的研究主要集中在两个方面：（1）开发 新的环化反应形成中环。 所有 现有的戒指类型（小型、普通型、中型和大型） 制备中等环的方法最不令人满意。 （二） 开发亲电环化反应， 由亲核试剂促进。 这种反应最近 发现并持有令人兴奋的承诺，大大扩大 简单炔在化学合成中的应用。

This research is being funded by the Organic Synthesis Program. Dr. Overman will continue his development of new ring forming reactions, particularly focussing on the medium ring range. This will provide some of the new tools required by the increasingly complex demands of agriculture and industry. The studies for the project focus in two areas: (1) Developing new cyclization reactions for forming medium rings. Of all types of rings (small, common, medium and large) existing methods are least satisfactory for preparing medium rings. (2) Developing electrophilic cyclization reactions that are promoted by nucleophiles. Reactions of this type were recently discovered and hold exciting promise for greatly expanding the utility of simple alkynes in chemical synthesis.