Acquisition of a Hybrid Mass Spectrometer

北卡罗来纳大学教堂山分校(UNC)环境科学与工程与化学系建立了一个联合质谱学设施。该基金的目标是支持和促进北卡罗来纳大学质谱学方面的化学研究和教学。该设施将为许多不同类别的化合物提供鉴定和结构特征的能力。一些主要使用者的项目的具体目的是深入了解多环芳烃对最终致癌物的激活机制；了解植物寄生虫中的甾醇代谢途径；合成非遗传蛋白质；描述昆虫中生态类固醇生物合成的中间产物，并确定控制昆虫发育的神经肽；了解-羧基-谷氨酰基(GLA)残基在凝血过程中的作用；表征有效的酶抑制剂，并分离和鉴定水中腐殖质的氯化和电离产物。为此，需要一种能够进行高分辨率和准确的质量测量、化学电离、碰撞激活电离、碰撞激活、气相色谱和快速原子轰击的质谱仪。最合适的仪器是混合质谱仪。

A joint Mass Spectrometry Facility has been created by the Department of Environmental Sciences and Engineering and Chemistry at the University of North Carolina at Chapel Hill (UNC). The objectives of the Facility are to support and promote chemical research and teaching in mass spectrometry at UNC. The Facility will provide the capability for identification and structural characterization of many different classes of compounds. Specific aims of some of the projects of the major users are to gain insight into mechanisms responsible for the activation of polycyclic aromatics to ultimate carcinogens; to understand sterol metabolic pathways in the plant parasites; to synthesize nongenetic proteins; to characterize intermediates in the biosynthesis of ecodysteroids in insects and to identify neuropeptides controlling insect development; to understand the role of -carboxyglutamyl (Gla) residues in blood coagulation processes; to characterize potent enzyme inhibitors and to separate and identify products of chlorination and ionization of humics in water. For these purposes, an mass spectrometer is needed that is capable of high- resolution and accurate mass measurements, chemical ionization, collisional activation ionization, collisional activation, gas- chromatography and fast-atom-bombardment. The most appropriate instrument is a hybrid-mass spectrometer.