Chemical Ionization of Laser Desorbed Peptides in a Fourier Transform Mass Spectrometer

这项研究由化学部门的分析和表面化学项目支持，将研究使用质谱法的一种变体来确定小蛋白质基本构建块序列的方法。潜在的应用包括诊断一些遗传疾病和监测代谢异常。由化学部分析和表面化学项目支持的%%%研究将使用激光解吸质谱和碰撞诱导解离来研究汽化肽的碎片化。傅里叶变换质谱法将允许许多连续的碰撞/测量周期，因此可以逐步分解肽。原子和分子碰撞物种都将被测试。

This research, supported by the Analytical and Surface Chemistry Program in the Chemistry Division, will investigate ways to determine the sequence of fundamental building blocks of small proteins using a variant of mass spectrometry. Potential applications include diagnosis of some genetic diseases, and monitoring of metabolic irregularities. %%% Research, supported by the Analytical and Surface Chemistry Program in the Chemistry Division, will use laser desorption mass spectrometry and collision-induced dissociation to study the fragmentation of vaporized peptides. Fourier Transform mass spectrometry will allow many sequential collision/measurement cycles, so that one may step-wise decompose the peptides. Both atomic and molecular collision species will be tested.