Phenylselenenyl Transfer Radical Reactions

化学部的合成有机项目将通过该奖项支持米德尔伯里学院化学系的杰弗里·h·拜尔斯博士的研究。该项目旨在开发新的碳-碳键形成反应。它将利用2-苯基硒基- 1,3-二羰基化合物，如丙二酸盐，与烯烃进行自由基反应。为了更好地了解反应的范围和局限性，将研究分子间和分子内的过程。基于这些研究，该方法将应用于几种简单但重要的有机化合物的合成，包括氨基酸、丁烷内酯和钛酸。这项研究是在合成方法学领域，将利用有机硒化合物开发一种新的碳-碳键形成反应，这是有机化学中最重要的反应之一。为了证明这种方法的适用性，我们将用它来合成几种简单但重要的有机分子。

With this award the Synthetic Organic Program of the Chemistry Division will support the research of Dr. Jeffrey H. Byers of the Department Chemistry of Middlebury College. The project is directed towards the development of new carbon-carbon bond forming reactions. It will utilize 2- phenylselenyl- 1,3-dicarbonyl compounds, such as malonates, in a free radical reaction with olefins. Both inter- and intramolecular processes will be investigated in order to gain a better understanding of the scope and limitations of the reaction. Based upon these studies, the methodology will be applied to the synthesis of several simple, but important classes of organic compounds, including amino acids, butanolides, and tetronic acids. %%% This research is in the area of synthetic methodology and will develop a new carbon-carbon bond forming reaction, one of the most important classes of reactions in organic chemistry, using organoselenium compounds. To demonstrate the applicability of this methodology, it will be used to synthesize several simple, but important classes of organic molecules.