Intramolecular Cyclization Reactions of Alkynyl Substituted Diazoketones

本研究的重点是α-重氮炔基取代酮与各种过渡金属相互作用形成的多环环体系。最初形成的酮卡宾中间体预计将在分子内加成到乙酰基pi键上，以产生乙烯基卡宾中间体。后者将被用来研究插入C-H键、加入pi键、1，2-氢和烷基迁移以及电环化的可能性。有了这个奖项，合成有机计划正在支持埃默里大学化学系的阿尔伯特·帕德瓦博士的研究。帕德瓦教授将专注于开发新的合成方法来生产卡宾中间体，从而制备不寻常的多环环体系。

The focus of this research is the formation of polycyclic ring systems by the interaction of alpha-diazo alkynyl substituted ketones with various transition metals. The initially formed ketocarbenoid intermediate is projected to undergo an intramolecular addition to the acetylenic pi-bond to produce a vinylcarbenoid intermediate. The latter will be probed to study the potential for insertion into C-H bonds, addition to pi-bonds, 1,2-hydrogen and alkyl group migration and electrocyclization. %%% With this award, the Synthetic Organic Program is supporting the research of Dr. Albert Padwa of the Department of Chemistry at Emory University. Professor Padwa will focus his work on the development of new synthetic methods for the production of carbenoid intermediates and, thus, the preparation of unusual polycyclic ring systems.