FASEB Summer Conference Transcription Regulation: Differentiation, Development and Disease, June 14-19, 1992, Copper Mountain, Colorado

分子遗传学家和发育生物学家面临的主要挑战之一是理解控制高等动物组织特异性基因表达的机制。在过去几年中，在这方面取得了广泛的进展。各种新的体内和体外系统已经发展起来，许多参与细胞类型特异性基因表达的转录因子被鉴定出来，编码这些因子的基因被分离出来。控制这些调节基因活性的激素和发育机制受到广泛的研究。本提案要求资助FASEB夏季会议，主题为转录调控：分化、发育和疾病。本次会议将聚集积极从事研究组织特异性基因表达各个方面的研究人员。除了讨论基因调控的基本机制外，还将重点讨论以下器官系统中正常和异常的基因调控：肝脏和胰腺、肌肉、血液和神经系统。我们还将召开专门会议，讨论发育和胚胎发生的调控。重点将放在脊椎动物，特别是哺乳动物的基因调控上。会议将于1992年6月14日至19日在科罗拉多州的铜山举行。会议的设计包括正式的幻灯片演示、非正式的海报会议、研讨会、小组讨论以及大量的个人互动机会。会议将总结当前对组织特异性基因表达的理解，并应传播新的信息、概念和方法。

One of the major challenges facing molecular geneticists and developmental biologists is understanding the mechanisms which control tissue specific gene expression in higher animals. During the past few years, there has been extensive progress in this direction. A variety of novel in vivo and in vitro systems have been developed, a number of transcription factors involved in cell- type specific gene expression were identified and the genes encoding such factors were isolated. The hormonal and developmental mechanisms controlling the activity of these regulatory genes are subject to extensive investigation. This proposal requests funds to finance a summer FASEB conference on the topic of Transcription Regulation: Differentiation, Development, and Disease. This meeting will congregate researchers actively engaged in studying various aspects of tissue specific gene expression. In addition to discussing the basic mechanism of gene regulation, special emphasis will be placed on discussion of both normal and aberrant gene regulation in the following organ systems: liver and pancreas, muscle, blood and the nervous system. We will also have special sessions dealing with the regulation of development and embryogenesis. The emphasis will be on gene regulation in vertebrates and expecially in mammals. %%% The conference will be held at Copper Mountain, Colorado from June 14-19, 1992. The meeting is designed to have formal slide presentations, informal poster sessions, a workshop, periods of group discussions, and plenty of opportunity for individual interaction. The conference will summarize the current understandings of tissue specific gene expression and should lead to dissemination of new information, concepts, and methodologies.