High-Precision Mass Spectrometry Imaging Facility

该提案旨在通过获取高分辨率离子迁移率质谱仪器，建立一个先进的化学制图设施，该仪器能够使用激光解吸/电离进行2D/3D空间分析，从厘米（整个组织）到微米（亚细胞）尺度。该设施将汇集来自纳米制造、化学工程、系统生物学、药物发现、环境生态学、农业生物科学和诊断科学等不同领域的世界领先的空间化学表型专业知识。该设施将通过将化学合成、纳米制造、生物偶联、蛋白质组学和代谢组学的突破应用于空间系统，实现转化研究。

This proposal aims to build an advanced chemical mapping facility through the acquisition of high-resolution ion mobility mass spectrometry instrumentation capable of 2D/3D spatial analysis using laser desorption/ionisation, from centimetre (whole tissues) to micrometer (sub-cellular) scale. This facility will create a concentration of world leading expertise in spatial chemical phenotyping from diverse fields including nanofabrication, chemical engineering, systems-biology, drug discovery, environmental ecology, agricultural biosciences and diagnostic sciences. The facility will enable translational research by applying breakthroughs in chemical synthesis, nanofabrication, bioconjugation, proteomics and metabolomics to spatial systems.