FASEB Conference on: Ubiquitin and Intracellular Degradation Protein, June 20-25, 1993, Saxtons River, Vermont

这是一项资金申请，以帮助支持将于1993年6月20-25日在佛蒙特州萨克斯顿河佛蒙特学院举行的一次会议(见上文)。这是一个两年一度的会议，由发起，由美国实验生物学学会联合会赞助和部分支持。会议的重点是细胞内蛋白质降解的机制，重点是泛素依赖的蛋白分解途径。泛素是一种小的、高度保守的真核蛋白质。它通过与其他蛋白质共价连接而在蛋白质分解中发挥作用，并作为蛋白质降解的可重复使用的识别信号。具体课程将包括泛素系统的生物化学、分子生物学和遗传学，泛素途径的靶点和功能，真核和原核细胞中的非泛素蛋白分解系统，蛋白质分解的识别信号，蛋白酶体，蛋白质分解和抗原提呈，原核生物中蛋白质分解的调节，以及细胞器中的蛋白质降解。

This is a request for funds to help support a conference (titled above) to be held June 20-25, 1993 at Vermont Academy, Saxtons River, VT. It is a biennial conference, initiated in 1989, which is sponsored and partially supported by the Federation of the American Societies of Experimental Biology. The focus of the conference is on the mechanisms of intracellular protein degradation with an emphasis on the ubiquitin-dependent proteolytic pathway. Ubiquitin is a small, highly conserved eukaryotic protein. It functions in protein breakdown by becoming covalently linked to other proteins and serves as a reusable recognition signal for proteolysis. Specific sessions will include the biochemistry, molecular biology and genetics of the ubiquitin system, targets and functions of the ubiquitin pathway, non- ubiquitin proteolytic systems in eucaryotic and in procaryotic cells, recognition signals for protein breakdown, the proteasome, proteolysis and antigen presentation enzymology and regulation of protein breakdown in prokaryotes, and protein degradation in organelles.