Cold Spring Harbor Laboratory Conference on The Ubiquitin Family

描述（由申请人提供）：泛素和泛素样多肽修饰靶蛋白已成为调节从代谢控制到细胞周期进程的许多细胞过程的主要机制。反过来，这些细胞内功能转化为泛素修饰系统在有机体水平上控制复杂调控程序的关键作用，包括分化、发育、昼夜节律和记忆存储。尽管我们对泛素修饰系统的生物学功能的了解在过去的十年中有了爆炸式的发展，但我们对这些系统在生化水平上如何运作的理解仍然相对有限。然而，过去几年见证了这些修饰系统组件的三维结构的可用性的巨大激增，这开始促进对这些蛋白质如何工作的更深层次的理解。此外，新的蛋白质组学和功能基因组学工具揭示了泛素修饰系统组分的新功能，并揭示了修饰酶和底物如何连接在一起形成网络。第三届冷泉港泛素会议的目的是将研究泛素修饰系统的生化和结构特性的研究人员与研究其生物功能和系统结构的研究人员聚集在一起。鉴于过去两年的快速发展，本次会议为与会者提供了一个令人兴奋的机会，以了解与他们自己的研究相关的最新发展。

DESCRIPTION (provided by applicant): Modification of target proteins by ubiquitin and ubiquitin-like polypeptides has emerged as a major mechanism for regulating many cellular processes ranging from metabolic control to cell cycle progression. In turn, these intracellular functions translate into key roles for ubiquitin modification systems in the control of complex regulatory programs at the organismal level including differentiation, development, circadian rhythms, and storage of memories. Although our knowledge of the biological functions of ubiquitin modification systems has exploded over the past decade, our understanding of how these systems operate at a biochemical level remains relatively modest. However, the past few years have witnessed a tremendous surge in the availability of three dimensional structures of components of these modification systems, which is beginning to foster a deeper understanding of how these proteins work. In addition, novel proteomic and functional genomic tools are revealing new functions for components of ubiquitin modification systems, and shedding light on how modification enzymes and substrates are linked together into networks. The objective of the third Cold Spring Harbor meeting on Ubiquitin is to bring together investigators who study the biochemical and structural properties of ubiquitin modification systems with investigators who focus on their biological functions and systems architecture. Given the rapid developments over the past two years, this meeting presents a exciting opportunity for participants to learn about recent developments that will be relevant to their own research. The program will include 8 sessions covering the components of ubiquitin modification systems and the cellular and organismal processes that they control. The sessions will be led by two outstanding and well-known investigators in these areas. With the exception of overview talks presented by the session chairs, all of the talks and posters to be presented will be selected from submitted abstracts, and most of the talks will be given by students, postdoctoral fellows and other younger investigators. It is expected that more than 275 scientists will attend. Of these, over half are likely to be graduate students and postdoctoral fellows. The subsequent meetings (2009 and 2011) will follow a similar format which will include topics that are highly relevant to the current research at the time of the meeting.