Cold Spring Harbor Laboratory Conference on The Ubiquitin Family

描述(申请人提供)：通过泛素和泛素样多肽修饰目标蛋白质已经成为调节从代谢控制到细胞周期进展的许多细胞过程的主要机制。反过来，这些细胞内功能转化为泛素修饰系统在生物体水平上控制复杂调控程序的关键角色，包括分化、发育、昼夜节律和记忆存储。尽管我们对泛素修饰系统的生物学功能的了解在过去十年中呈爆炸式增长，但我们对这些系统如何在生化水平上运行的了解仍然相对较少。然而，在过去的几年里，这些修饰系统组件的三维结构的可用性出现了巨大的激增，这开始促进对这些蛋白质如何工作的更深入的理解。此外，新的蛋白质组学和功能基因组学工具正在揭示泛素修饰系统组件的新功能，并揭示修饰酶和底物如何连接成网络。第三届泛素冷泉港会议的目标是将研究泛素修饰系统的生化和结构特性的研究人员与专注于其生物功能和系统架构的研究人员聚集在一起。鉴于过去两年的快速发展，这次会议为与会者提供了一个令人兴奋的机会，让他们了解与自己的研究相关的最新发展。 该计划将包括8个会议，涵盖泛素修饰系统的组件及其控制的细胞和生物过程。会议将由这些领域的两名杰出和知名的调查人员领导。除了会议主席的概述演讲外，所有的演讲和海报都将从提交的摘要中挑选出来，大部分演讲将由学生、博士后研究员和其他年轻的研究人员进行。预计将有超过275名科学家参加。其中，超过一半的人可能是研究生和博士后研究员。 随后的会议(2009年和2011年)将采用类似的形式，其中将包括与会议时的当前研究高度相关的议题。

DESCRIPTION (provided by applicant): Modification of target proteins by ubiquitin and ubiquitin-like polypeptides has emerged as a major mechanism for regulating many cellular processes ranging from metabolic control to cell cycle progression. In turn, these intracellular functions translate into key roles for ubiquitin modification systems in the control of complex regulatory programs at the organismal level including differentiation, development, circadian rhythms, and storage of memories. Although our knowledge of the biological functions of ubiquitin modification systems has exploded over the past decade, our understanding of how these systems operate at a biochemical level remains relatively modest. However, the past few years have witnessed a tremendous surge in the availability of three dimensional structures of components of these modification systems, which is beginning to foster a deeper understanding of how these proteins work. In addition, novel proteomic and functional genomic tools are revealing new functions for components of ubiquitin modification systems, and shedding light on how modification enzymes and substrates are linked together into networks. The objective of the third Cold Spring Harbor meeting on Ubiquitin is to bring together investigators who study the biochemical and structural properties of ubiquitin modification systems with investigators who focus on their biological functions and systems architecture. Given the rapid developments over the past two years, this meeting presents a exciting opportunity for participants to learn about recent developments that will be relevant to their own research. The program will include 8 sessions covering the components of ubiquitin modification systems and the cellular and organismal processes that they control. The sessions will be led by two outstanding and well-known investigators in these areas. With the exception of overview talks presented by the session chairs, all of the talks and posters to be presented will be selected from submitted abstracts, and most of the talks will be given by students, postdoctoral fellows and other younger investigators. It is expected that more than 275 scientists will attend. Of these, over half are likely to be graduate students and postdoctoral fellows. The subsequent meetings (2009 and 2011) will follow a similar format which will include topics that are highly relevant to the current research at the time of the meeting.