Synthetic Organosulfur Chemistry

本研究的重点是自然发生和合成有机硫化合物的化学性质。对葱属植物（包括大蒜和洋葱及其同类）成分的持续研究，将解决主要调味剂的光学活性问题以及酶在其形成中的作用。有机合成新试剂和新方法的发明将包括基于Ramberg-Backland反应的新试剂和新方法及其在环戊二烯和1,3-烯的新路线中的应用。将进行不寻常的生理活性有机硫天然产物和非天然硫化合物的全合成。研究高活性小有机硫化合物的微波光谱。合成新的多硫醇感兴趣的配体和/或材料科学将进行。有了这个更新奖，合成有机项目将支持纽约州立大学奥尔巴尼分校化学系的埃里克·布洛克博士的研究，他将研究自然产生的和合成的有机硫化合物。在天然产品领域，重点将放在高度不稳定的化合物上，这些化合物构成了包括大蒜和洋葱在内的葱属植物的气味和风味。在合成领域，有机硫化合物将被用于生产对隔离重金属有用的新化合物或用于合成新材料。

The focus of this research is the chemistry of both naturally occurring and synthetic organosulfur compounds. Continuing research on the constituents of the Allium family, which contains garlic and onions and their allies, will address the question of optical activity of primary flavorants and the role of enzymes in their formation. The invention of new reagents and methods for organic synthesis will include those based on the Ramberg-Backland reaction and their application to new routes to cyclopentadienes and 1,3-eneynes. The total synthesis of unusual physiologically active organosulfur natural products and unnatural sulfur compounds will be carried out. The microwave spectroscopy of highly reactive small organosulfur compounds will be studied. Synthesis of new polythiols of interest as ligands and/or in material science will be carried out. %%% With this Renewal award, the Synthetic Organic Program is supporting the research of Dr. Eric Block of the Department of Chemistry at SUNY Albany, who will study both naturally occurring and synthetic organosulfur compounds. In the natural product area, the emphasis will be on the highly labile compounds which account for the odor and flavor of the Allium family which includes garlic and onions. In the synthetic area, organosulfur compounds will be utilized in for the production of new compounds useful in sequestering heavy metals or in the synthesis of new materials.