Development of Bioerodible Polymer Matrices for Osteoblast Growth and Maturation

这项研究拨款将支持开发一个 可生物降解的聚合物基质， 成骨细胞和成骨细胞前体。 其目的是为了 同时聚合物降解和细胞生长和成熟 导致骨样组织的产生。 目标 1）设计和开发可降解三维 聚合物和聚合物/陶瓷材料的基质， 表征这些新的基质; 2）接种成骨细胞 在新制造的三维可生物降解聚合物上 基质，并在体外研究成骨细胞粘附和生长;以及 3)在体内环境中研究成骨细胞-聚合物基质 表征其骨诱导能力，或 骨传导的 这项研究很重要，因为它可能导致发展 用于骨不连的新材料，外科 关节固定术、颅面缺损手术和涂层， 矫形植入物

This research grant will support the development of a biodegradable polymeric matrix that would support the growth of osteoblasts and osteoblast precursors. The intent is to have simultaneous polymer degradation and cell growth and maturation leading to the generation of bone-like tissues. The objectives are 1) to design and develop degradable three-dimensional matrices of polymers and polymer/ceramic materials and to fully characterize these novel matrices; 2) to seed osteoblast cells onto the newly created three-dimensional biodegradable polymer matrices and study osteoblast adherence and growth in vitro; and 3) to study osteoblast-polymer matrices in an in vivo environment characterizing their ability to be osteoinductive or osteoconductive. This research is important since it could lead to the development of new materials for use in non-unions of bones, surgical arthrodeses, cranio-facial defect procedures, and coating for orthopedic implants.