The Biology of Heat Shock Proteins and Molecular Chaperones Conference, May 4-8, 1994, Cold Spring Harbor, NY

自1991年冷泉港应激蛋白会议以来，关于热休克蛋白和分子伴侣在蛋白质转运和蛋白质折叠过程中的作用有了大量的新信息。由于它们在涉及蛋白质生物发生的基本过程中新发现的基本作用，热休克蛋白和分子伴侣已经引起了基础科学中许多传统科学学科以及包括传染病、癌症和心脏病在内的许多医学专业的兴趣。因此，这次会议，按照冷泉港会议的传统，将强调这些新发现。1994年会议的组织者是Richard I. Morimoto， Susan Lindquist和Costa Georgopoulos他们都曾是这次会议和其他关于热休克反应的国际会议的组织者。会议将有8个讲座和2个海报环节。会议的工作大纲包括：i -热休克基因表达的调控，ii -分子伴侣子-结构和生化特性，iii -分子伴侣子-蛋白质折叠和细胞内运输，iv -分子伴侣子的其他功能，v -分子伴侣子的识别特性，VI-蛋白质修饰和蛋白质水解，vii -应激保护-从细胞到生物体，viii -免疫生物学，感染性疾病和病理生理学。每届会议将由一名特邀发言者主持，由八至九场演讲组成，相当于四至五名特邀发言者，每届会议的其余发言者从提交的摘要中选出。除了高级研究人员的出席和报告外，还将特别注意鼓励研究生和博士后参加讲座或海报会议。所谓的热休克蛋白或应激反应蛋白对细胞的非正常生命至关重要，并在许多不利条件下保护细胞。其中一些蛋白质参与引导其他重要的细胞蛋白质到达细胞中的适当位置。它们在帮助细胞适应环境快速变化中的保护作用也引起了那些研究生物体异常或患病状态的人的兴趣。热休克蛋白的研究取得了很大进展。1994年冷泉港热休克蛋白和分子伴侣会议的目的是将科学家聚集在一起讨论他们的最新研究成果。会议的形式是鼓励年轻的科学家、研究生、博士后、初级教师以及高级研究人员展示他们的最新工作。每届会议将由一名特邀发言者主持，由八至九场演讲组成，相当于四至五名特邀发言者，每届会议的其余发言者从提交的摘要中选出。将特别注意鼓励研究生和博士后参加海报会议的讲座，以及高级研究人员的出席和报告。＊＊＊

9317819 Grodzicker There has been a significant amount of new information on the role of heat shock proteins and molecular chaperons in the process of protein transport and protein folding since the 1991 Cold Spring Harbor meeting on Stress Proteins. Due to their newly discovered fundamental roles in essential processes involving protein biogenesis, heat shock proteins and molecular chaperons have drawn interest from a number of traditional scientific disciplines in the basic sciences as well as numerous medical specialties including infectious diseases, cancer and heart disease. Therefore, this meeting, in the tradition of Cold Spring Harbor meetings will emphasize many of these new discoveries. The organizers for the 1994 meeting are Richard I. Morimoto, Susan Lindquist and Costa Georgopoulos all of whom have been previous organizers of this and other international meetings on the heat shock response. The meeting will have eight lecture and two poster sessions. The working outline for the sessions includes: I-The Regulation of Heat Shock Gene Expression, II-Molecular Chaperons - Structure and Biochemical Properties III-Molecular Chaperons - Protein Folding and Intracellular Transport, IV-Other Functions for Molecular Chaperons, V-Recognition Properties of Molecular Chaperones, VI- Proteins Modification and Proteolysis, VII-Protection from Stress - From Cells to Organisms, and VIII-Immunobiology, Infectious Diseases and Pathophysiology. Each session will be chaired by an invited speaker and be comprised of eight to nine talks, corresponding to four to five invited speakers with the remaining speakers for each session selected from submitted abstracts. Particular attention will be paid to encourage participation in the lecture or poster sessions by graduate students and postdoctoral fellows in addition to attendance and presentations by senior investigators.%%% What have been called heat shock proteins or stress response proteins are essential for the no rmal life of cells as well as protecting them under many types of adverse conditions. Some of these proteins are involved in guiding other important cellular proteins to their proper location in the cell. Their protective role in helping cells to adapt to rapid changes in the environment has also been of interest to those studying abnormal or diseased states of the organism. Much progress has been made in the study of heat shock proteins. The purpose of the 1994 Cold Spring Harbor Conference on Heat Shock Proteins and Molecular Chaperone is to bring together scientists to discuss the latest results of their research. The meeting has a format to encourage younger scientists graduate students, postdoctoral fellows, and junior faculty, as well as senior investigators to present their latest work. Each session will be chaired by an invited speaker and be comprised of eight to nine talks, corresponding to four to five invited speakers with the remaining speakers for each session selected from submitted abstracts. Particular attention will be paid to encourage participation in the lecture of poster sessions by graduate students and postdoctoral fellows in addition attendance and presentations by senior investigators. ***