Workshop on Extremozymes: Biocatalysis under Extraordinary Conditions

亚当斯9404992对从栖息在非常规生态系统中的生物体中分离的酶的研究已经使人们认识到，生物催化不需要被限制在温和的条件下，并且可以被认为在pH值、温度、压力、离子和溶剂环境下，尽管对生物系统是破坏性的。 然而，在这种极端条件下生物功能的内在基础才刚刚开始得到解决，因为可以被称为极端酶的应用。 除了扩大在极端环境中寻找新的和有趣的酶之外，重要的是要承担目前蛋白质结构和功能研究的复杂性。 此外，那些熟悉生物催化潜在用途的人必须更加意识到与极端酶鉴定研究相关的机遇和挑战。 最后，鉴于从极端酶研究中获得的信息，对不太稳定的酶进行修饰以提高其稳定性和活性范围仍然是可能的。 本次研讨会将汇集来自学术界，政府和工业界的代表，提供关于极端酶及其在现代生物催化中的地位的观点。 贡献将涵盖基本和应用方面，努力描述令人兴奋的进展，以及确定在极端条件下使用生物催化剂的潜在机会。 ***

Adams 9404992 The study of enzymes isolated from organisms inhabiting unconventional ecosystems has led to the realization that biocatalysis need not be constrained to mild conditions and can be considered at pH's, temperatures, pressures, ionic and solvent environments long though to be destructive to biological systems. However, the intrinsic basis for biological function under such extreme conditions is only starting to be addressed, as are applications for what can be called extremozymes. In addition to expanding the search for novel and interesting enzymes from extreme environments, it is important to bring to bear the current sophistication in the study of protein structure and function. Also, those familiar with potential uses of biocatalysis must become more aware of the opportunities and challenges associated with the identification study of extremozymes. Ultimately, given the information acquired from the study of extremozymes, modification to less stable enzymes to improve their ranges of stability and activity remains a possibility. %%% This workshop will bring together representatives from academia, government and industry to provide a perspective on extremozymes and their place in modern biocatalysis. Contributions will cover both fundamental and applied aspects in an effort to describe exciting developments in progress as well as to identify potential opportunities for the use of biological catalysts under extreme conditions. ***