Organic Osmolyte Channels and Cell Volume Regulation in Fish Erythrocytes

9505567戈尔茨坦体细胞必须保持其体积恒定才能正常运作。在生理和病理条件下，人类和动物细胞的体积都面临着持续的威胁。在这项提案中，戈尔茨坦博士将研究细胞和分子机制，使细胞在面临细胞周围环境的渗透紊乱时保持恒定的体积。实验模型将是溜冰鞋的红细胞。他在过去成功地使用了这个模型来开始阐明细胞膜中的生理过程，这些过程涉及在细胞外干扰后将细胞体积调整到正常水平。他将继续这些研究，以及其他处理细胞体积变化向细胞膜中的体积调节机制发出信号的方式的研究。这些研究将有助于更好地理解细胞体积调节的基本道德现象的生理基础。***

9505567 Goldstein Body cells must maintain their volume constant in order to function properly. Both humans and animal cells face constant threats to their volumes under both physiological and pathological conditions. In this proposal, Dr. Goldstein will be examining the cellular and molecular mechanisms that permit cells to maintain constant volume in the face of osmotic disturbances in the environment surrounding cells. The experimental model will be the red blood cell of the skate. He has used this model successfully in the past to begin elucidating the physiological processes in the cell membrane that are involved in adjusting cell volume back to normal after extracellular disturbances. He will continue with these studies as well as others that deal with the ways in which cell volume changes are signaled to volume-adjustilg mechanisms operating in the cell membrane. The studies will lead to a better understanding of the physiological basis of the fundamethal phenomemon of cell volume regulation. ***