U.S.-Japan Cooperative Science: Development of X-ray CCD Detectors and their Applications to Synchrotron Radiation Time-resolved Solution Scattering

9513129 Hodgson该奖项支持斯坦福大学的Keith Hodgson博士和日本筑波国家高能物理实验室的Yoshiyuki Ameiya博士之间为期三年的合作研究项目。该项目代表了一个利用同步辐射进行小角X射线散射(SAXS)时间分辨解决方案的合作仪器开发计划。新的仪器将应用于选定的蛋白质折叠和变构转变方面的合作研究项目。研究计划的主要方面是：1)参与SAXS研究用先进的基于电荷耦合器件的探测器的联合开发；2)合作开发在比目前使用的更快的时间域(低至约1毫秒)内研究结构变化的技术；以及3)利用日本光子工厂的这些开发，然后在斯坦福同步辐射实验室(SSRL)的超高通量束流线上进行生物系统的实际结构研究。美国研究人员将从参与日本先进X射线探测器系统的开发中受益匪浅，而日本合作者将在SSRL获得新的合成多层单色仪的经验。这一提议实现了该计划的共同努力目标，即将两个国家的最先进方法纳入联合国际合作努力。***

9513129 Hodgson This award supports a three year cooperative research project between Dr. Keith Hodgson of Stanford University and Dr. Yoshiyuki Amemiya of the National Laboratory for High Energy Physics in Tsukuba, Japan. This project represents a program of cooperative instrument development for time- resolved solution, small-angle x-ray scattering (SAXS) using synchrotron radiation. The new instrumentation will be applied to selected collaborative research projects on protein folding and allosteric transitions. The principal aspects of the research plan are 1) to participate in the joint development of advanced CCD-based detectors for SAXS studies; 2) to collaborate on the development of techniques to investigate structural changes in a faster time domain (down to about 1 ms) than currently utilized, and 3) to utilize these developments at the Photon Factory in Japan and then on an ultra high flux beam line at the Stanford Synchrotron radiation Laboratory (SSRL) for actual structural studies of biological systems. The U.S. investigators will benefit significantly by participating in the development of advanced x-ray detector systems in Japan whereas the Japanese collaborators will gain experience with the new synthetic multilayer monochromator at SSRL. This proposal fulfills the objectives of the Program in its joint endeavor bringing state of the art methods from two countries into a joint international collaborative effort. ***