The Biology of Heat Shock Proteins and Molecular Chaperones: Meeting to be held May 1-5, 1996 at Cold Spring Harbor, NY

951370 Grodzicker这项建议是请求为1996年5月1日至5日在冷泉港实验室举行的分子伴侣和热休克反应会议提供部分财政支助。关于热休克蛋白合成、蛋白质折叠、转运和分泌的作用，已经有了大量的新信息。此外，在这些热休克蛋白和伴侣蛋白的生化性质、编码这些蛋白的基因的调控以及热休克蛋白在广泛的人类疾病中的作用、调节和功能方面也取得了实质性的进展。热休克蛋白和分子伴侣领域发展迅速，吸引了基础科学中许多传统科学学科的兴趣，并涵盖了包括传染病、癌症、心脏病和神经退行性疾病在内的许多生物医学研究领域。这次会议沿袭了冷泉港会议的传统，将强调这些领域的新发现。会议将包括七个讲座和三个海报会议。拟议的会议包括：I-依赖伴侣的蛋白质折叠的生化和生物物理方面，II-前体蛋白导入和折叠到细胞器和分泌到细胞外空间，III-蛋白质折叠，IV-伴侣在识别蛋白质降解机制中的作用，V-编码伴侣的基因的转录和转录后调控，VI-耐受胁迫：保护关键细胞靶标免受蛋白质损伤，以及VII-疾病中的应激反应。每期会议将由一名特邀演讲者主持，并有8至9次口头陈述，每期会议只有3至4次演讲是预先邀请的演讲者。每届会议的其余发言者将从提交的摘要中选出，以反映不同的参与情况，并认可新的调查人员。将特别注意鼓励研究生、博士后研究员和新的研究人员参加讲座或海报会议，以及该领域主要科学家的出席和介绍。***

951370 Grodzicker This proposal is a request for partial financial support for a meting on Molecular Chaperones and the Heat Shock response to be held from May 1-5, 1996 at Cold Spring Harbor Laboratory. There has been a significant amount of new information on the role of heat shock proteins synthesis, protein folding, transport and secretion. In addition, there has been substantial progress on the biochemical properties of these heat shock proteins and chaperones, on the regulation of the genes that encode these proteins, and on the role, regulation and function of heat shock proteins in a wide range of human diseases. the field of heat shock proteins and molecular chaperones has gown rapidly and draws interest from a number of traditional scientific disciplines in the basic sciences and has embraced numerous areas of biomedical research including infectious diseases, cancer, heart disease and neurodegenerative disease. This meeting, in the tradition of Cold Spring Harbor meetings, will emphasize new discoveries in these areas. The meeting will include seven lecture and three poster sessions. The proposed sessions include: I-Biochemical and biophysical aspects of chaperone-dependent protein folding, II-Import and folding of precursor proteins into organelles and secretion into the extracellular space, III-The protein folding, IV-The role of chaperones in recognition of the protein degradative machinery, V-The transcriptional and post-transcriptional regulation of genes encoding chaperones, VI-Stress tolerance: Protection of critical cellular targets against protein damage, and VII-The Stress Response in Disease. Each session will be chaired by an invited speaker and have eight to nine oral presentations of which only 3-4 talks per session will be pre-invited speakers. The remaining speakers for each session will be selected from submitted abstracts to reflect diverse participation and to recognize new investigators. Particular attention will be paid to encourage participation in the lecture or poster sessions by graduate students, postdctoral fellows, and new investigators in addition to attendance and presentations by leading scientists in the field. ***