FASEB Conference: "Transport ATPases" will be held at Copper Mountain, Colorado from 8-19-96 to 8-22-96

9600496 Scarpa/Carafoli这是关于“运输atp酶”的第一届夏季会议的部分资金申请，该会议将于1996年8月19日至22日在科罗拉多州的铜山举行，由美国实验生物学学会联合会（FASEB）主持。会议的主要目的是汇集150名来自不同学科的研究人员，他们研究各种atp酶的不同方面，就这些重要酶的结构、功能和调控交换意见和最新信息。这些科学家代表了包括生物化学、生物学、生物物理学、化学、遗传学、分子生物学、药理学、物理学和生理学在内的学科骨干。转运atp酶广泛分布于细胞和亚细胞器中。在正向传输模式下，它们利用ATP形式的化学能来构建离子梯度。这种能量转导是兴奋性、收缩性、分泌和整体细胞功能的关键。这些ATP酶消耗的ATP（以及营养物质和氧气）的数量是非常大的。这一领域取得的巨大进展是显而易见的：已经克隆了几个atp酶；同工酶已经被发现；荷尔蒙对表达的调节已被证实；x射线衍射、低角衍射和定点诱变提供了一些结构见解；新的转运atp酶，如用于Mg2+转运的atp酶已经被描述和表征。本次会议将重点讨论近年来不同atp酶在结构、调控和生理意义上的变化。这种相互作用的环境将极大地激发合作努力，并有助于确定未来研究的新方向，以及已经成功地用于已建立的atp酶的新工具和方法，这可能应用于新发现的转运酶。运输三磷酸腺苷酶是一种能够利用储存在三磷酸腺苷中的能量来跨细胞膜运输各种离子或分子的蛋白质。这种形式的能量转导参与了许多生物过程，如神经传导、肌肉收缩、分泌和整体细胞稳态。这次会议将尝试整合各种运输atp酶的知识，希望找到统一的特征，以及研究新发现的运输酶的新方法。＊＊＊

9600496 Scarpa/Carafoli This is an application for partial funding of the first summer conference on "Transport ATPases" to be held under the auspices of the Federation of American Societies for Experimental Biology (FASEB) from August 19-22, 1996 at Copper Mountain, Colorado. The conference has the major aim of bringing together one hundred and fifty investigators from a large number of disciplines working on different aspects of various ATPases to exchange ideas and the latest information on structure, function and regulation of these important enzymes. These scientists represent a cadre of disciplines which include biochemistry, biology, biophysics, chemistry, genetics, molecular biology, pharmacology, physics and physiology. Transport ATPases are widely distributed in cells and subcellular organelles. In the forward transport mode, they utilize chemical energy il the form of ATP to build ionic gradients. This energy transduction is key to excitability, contractility, secretion, and overall cell function. The amount of ATP (and therefore nutrients and oxygen) consumed by these ATPases is extremely large. Immense progress that has taken place in this field is evident: several ATPases have been cloned; isozymes have been found; hormonal regulation of expression has been documented; several structural insights have been provided by x-ray diffraction, low angle diffraction and site-directed mutagenesis; new transport ATPases such as the one for Mg2+ transport have been described and characterized. This conference will focus on the variations in structure, regulation and physiological significance among different ATPases which have been described during the last few years. The interactive environment should greatly stimulate collaborative efforts and help identify new directions for future research in addition to new tools and approaches, already successful for established ATPases, which may be applied to newly discovered transporting enzymes. %%% Transport ATPases are proteins that are capabl e of utilizing the energy stored in ATP to transport various ions or molecules across cellular membranes. This form of energy transduction is involved in many biological processes, such as nerve conduction, muscle contraction, secretion, and overall cellular homeostasis. This meeting will try to integrate knowledge on the various transport ATPases in the hopes of finding unifying features as well as novel approaches to the study of newly discovered transporting enzymes. ***