Purchase of a 400 MHz NMR Spectrometer

化学研究仪器和设施计划的这一奖项将帮助布兰代斯大学化学系获得400 MHz NMR光谱仪。这些设备将加强若干领域的研究，包括：（1）酶抑制剂的合理设计和酶作用机理的研究，（2）具有生物活性的天然产物的合成和作用机理的研究，（3）胰蛋白酶的结构/功能研究和肌苷一磷酸脱氢酶的作用机理研究，（4）主要天然产物的短合成和新合成反应的开发，（5）NMR和离子对结构和动力学的蛋白质动力学，和（6）生物活性天然产物的全合成。 核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱分析技术是必不可少的。这些NMR研究的结果在聚合物、催化和生物学等领域都很有用。

This award from the Chemistry Research Instrumentation and Facilities Program will assist the Department of Chemistry at Brandeis University to acquire a 400 MHz NMR Spectrometer. This equipment will enhance research in a number of areas including the following: (1) rational design of enzyme inhibitors and studies of enzyme mechanisms, (2) synthesis and mechanistic studies of biologically active natural products, (3) structure/function studies of trypsin and mechanistic studies of inosine monophosphate dehydrogenase, (4) short syntheses of major natural products and development of new synthetic reactions, (5) protein dynamics by NMR and ion pair structure and dynamics, and (6) total synthesis of biologically active natural products. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometry is essential to chemists who are carrying out frontier research. The results from these NMR studies are useful in the areas such as polymers, catalysis, and in biology.