Hydrogen Bonded and Non-Hydrogen Bonded Sources of Structural Stability and Cooperativity

在有机动力学项目的资助下，威斯康星大学的盖尔曼教授正在研究分子关联中的非共价键因素。研究的重点是确定疏水相互作用、pi堆积和偶极-偶极吸引等因素对分子识别和折叠的贡献。正在准备模型化合物来测试每个因素，核磁共振光谱是分析技术。生物和材料中的分子系统结合在一起形成功能组件，具有诸如强度、化学反应催化和一般生物活性等有益特性。这项调查旨在确定导致这些功能组件形成的一些个别因素的特征。

With funding from the Organic Dynamics Program, Professor Gellman of the University of Wisconsin is investigating the noncovalent bonding factors in molecular associations. The focus of the research is to determine the contributions that factors such as hydrophobic interactions, pi stacking and dipole-dipole attraction make on molecular recognition and folding. Model compounds are being prepared to test each factor and NMR spectroscopy is the analysis technique. Molecular systems in biology and materials associate to form functional assemblies that have beneficial properties such as strength, chemical reaction catalysis and general biological activity. This investigation is designed to characterize some of the individual factors responsible for the formation of these functional assemblies.