Synthesis of Novel Materials Utilizing Sialic Acid Derivatives as Peptide Equivalents

这项研究的重点有三个方面。 首先，方法将 开发用于制备一类新材料， 具有羧基和氨基末端的氨基酸的缩合 聚合唾液酸低聚物。 二是扎实的帮扶方式， 开发用于制备一类新材料， 唾液酸作为肽等价物。 第三，解决方案阶段 这些材料的构象将使用核磁共振检查。 共振（NMR）光谱和分子建模。 教育 活动涉及化学教育计划，旨在发展 有机化学中的发现式学习方法随着这个职业 奖，合成有机计划支持的研究和 教育活动的杰奎琳Gervay博士的部门 亚利桑那大学的化学系。 格威教授会让她 在开发新材料的合成路线方面的研究工作， 将选择性地取代重要的生物识别过程。 的 合成靶包括基于唾液酸的低聚化合物， 将破坏蛋白质-蛋白质相互作用， 静电相互作用 Gervay博士的教育活动包括 一个化学教育项目，旨在开发基于发现的 有机化学的学习方法

The focus of this research is threefold. First, methods will be developed for the preparation of a new class of materials derived from condensation of amino acids with both carboxy and amino termini of polymeric sialic acid oligomers. Second, solid support methods will be developed for the preparation of a new class of materials utilizing sialic acid as peptide equivalents. Third, the solution phase conformation of these materials will be examined using nuclear magnetic resonance (NMR) spectroscopy and molecular modeling. Educational activities involve a program in chemical education directed to developing discovery based learning methods in organic chemistry. With this CAREER award, the Synthetic Organic Program supports the research and educational activities of Dr. Jacqueline Gervay of the Department of Chemistry at the University of Arizona. Professor Gervay will focus her research efforts on developing synthetic routes to novel materials that will selectively replace important biological recognition processes. The synthetic targets include sialic acid based oligomeric compounds that will disrupt protein-protein interactions involving both helical and electrostatic interactions. Dr. Gervay's educational activities involve a program in chemical education directed to developing discovery based learning methods in organic chemistry.