CAREER: In-situ Determination of Pesticides and Other Environmental Pollutants with a Fiber Optic, Surface Resonance Based Sensor

该学院早期职业发展(CALEAR)项目由分析和表面化学计划支持，专注于新型光纤传感器的开发和表征，用于测定实际环境样品中十亿分之几的农药浓度。布克什教授和他在亚利桑那州立大学的学生将开发各种这样的传感器，包括抗体固定化设备，该设备利用其表面等离子体共振信号的衰减全反射来实现选择性和灵敏度。探头的几何形状将针对这一应用进行优化，当系统参数变化时，将使用多变量校准算法来提高数据质量。这个职业研究项目还将使本科生和研究生在分析测量涉及复杂的现实世界样本时接触到多变量方法的力量。布克什教授还将指导对科学事业感兴趣的残疾学生。环境中农药浓度的测定是一个重要的健康问题，由于现实世界样品成分的多变性，这一问题非常复杂。布克什教授和他在亚利桑那州立大学的学生将开发基于抗体/抗原反应的光纤传感器，这些传感器产生的分析信号可以随着时间的推移得到可靠的解释。这个职业项目将为学生在一个具有巨大社会重要性的领域提供一个激动人心的研究经验。利用与光纤传感器探针耦合的抗体/抗原反应的极端灵敏度和选择性，将利用这些反应后的表面等离子体共振信号的衰减全反射。除了教授学生有用的化学应用的教学价值外，布克什教授还将指导对科学事业感兴趣的残疾学生。

This Faculty Early Career Development (CAREER) project, supported in the Analytical and Surface Chemistry Program, focusses on the development and characterization of novel fiber-optic sensors for the determination of part-per-billion concentrations of pesticides in real environmental samples. Professor Booksh and his students at Arizona State University will develop a variety of such sensors including antibody immobilized devices that utilize attenuated total reflectance of their surface plasmon resonance signals in order to achieve selectivity and sensitivity. The probe geometry will be optimized for this application and multivariate calibration algorithms will be used to improve data quality when system parameters vary. This CAREER research project will also expose students at the undergraduate and graduate levels to the power of multivariate methods when analytical measurements involve complex real world samples. Professor Booksh will also mentor disabled students interested in scientific careers. The determination of the concentrations of pesticides in the environment is an important health problem that is highly complex due to the variability of real world sample composition. Professor Booksh and his students at Arizona State University will develop fiber-optic sensors based on antibody/antigen reactions that produce analytical signals that can be reliably interpreted over time. This CAREER project will provide students with a stimulating research experience in an area of immense societal importance. The extreme sensitivity and selectivity of antibody/antigen reactions coupled with fiber-optic sensor probes will be exploited using attenuated total reflectance of surface plasmon resonance signals that follow these reactions. In addition to the pedagogical value of teaching students useful applications of this chemistry Professor Booksh will mentor disabled students interested in scientific careers.