The Acquisition of an Electrospray Mass Spectrometer Interfaced with an HPLC

* 9708881 SWEENEY化学研究仪器和设施奖 （CRIF）计划将协助亨特学院化学系 在获得电喷雾（ESI）质谱仪接口， 用HPLC这一设备将加强若干领域的研究 包括：（1）超分子卟啉的自组装 阵列，（2）金属氧化物的锝络合物，（3）丝裂霉素-DNA 加合物，（4）糖醛转移的环加成途径，和（5） 相邻连接的聚醚的合成。 质谱（MS）是用于探测紧密结构的技术， 详细信息，并获得大量的分子组成， 有机、生物有机和有机金属分子。的加入 电喷雾技术将质谱的范围扩展到蛋白质和核酸 酸的分子量远远超过任何其他技术。使用 电喷雾电离结合高分辨率提供了 质谱分析的最新技术它为化学家提供了 一个最强大的工具，可用于表征 化合物.在质谱分析中获得这种能力是 对许多领域的前沿研究至关重要， 化学. ***

*** 9708881 SWEENEY This award from the Chemistry Research Instrumentation and Facilities (CRIF) Program will assist the Department of Chemistry at Hunter College of CUNY in acquiring an electrospray (ESI) mass spectrometer interfaced with an HPLC. This equipment will enhance research in a number of areas including the following: (1) self-assembly of supramolecular porphyrin arrays, (2) technetium complexes of metal oxides, (3) mitomycin-DNA adducts, (4) the cycloaddition path to glycosal transfer, and (5) synthesis of adjacently linked polyethers. Mass spectrometry (MS) is a technique used to probe intimate structural details and to obtain the molecular compositions of a vast array of organic, bioorganic, and organometallic molecules. The addition of the technique of electrospray extends the range of MS to protein and nucleic acid molecular weights far beyond any other technique. The use of electrospray ionization in combination with high resolution provides the latest technique available in mass spectrometry. It affords the chemist one of the most powerful tools available for the characterization of compounds. The acquisition of this capability in mass spectrometry is essential for the prosecution of frontier research in many fields of chemistry. ***