Asymmetric Amino Acid Synthesis by Imine Hydroformylation

宾夕法尼亚大学化学学部的启动基金支持Marisa C. Kozlowski教授的研究。本研究的主题是通过过渡金属催化亚胺的氢甲酰化合成α -氨基酸。提出了非映体和对映体两种变体。多步反应涉及顺序烯烃氢甲酰化，亚胺形成，亚胺氢甲酰化将使用单一催化剂进行。机理研究将阐明反应的过程，并有助于设计合适的催化剂体系。本文研究的合成工艺的成功开发代表了对现有方法的重大改进，因为可以从现成的起始材料廉价地生产大量手性氨基酸。这类材料在催化和不对称合成中具有重要意义。

This starter grant award of the Chemistry Division to the University of Pennsylvania supports the research of Professor Marisa C. Kozlowski. The theme of the research is the asymmetric synthesis of alpha-amino acids by transition-metal catalyzed hydroformylation of imines. Both diastereo- and enantioselective variants are proposed. Multistep reactions involving sequential alkene hydroformylation, imine formation, and imine hydroformylation will be performed using a single catalyst. Mechanistic studies will elucidate the course of the reactions and aid in the design of appropriate catalyst systems. The successful development of the synthetic process studied here represents a significant improvement over existing methods in that a large number of chiral amino acids can be produced inexpensively from readily available starting materials. Such materials are important in catalysis and asymmetic synthesis.