POWRE: Synthesis of Alkaloids via a Photochemical Methodology

该奖项由“妇女从事研究和教育的专业机会”（POWRE）项目颁发，旨在资助蒙大拿州立大学辛西娅·麦克卢尔教授的研究和教育活动。该奖项由美国国立卫生研究院通过机构间转移向国家科学基金会提供资金。这项由POWRE奖支持的研究旨在开发一种新的合成方法，用于生产具有生物医学意义的氮杂环。麦克卢尔教授是一名有建树的有机磷化学研究员，他将对一系列氮杂双环系统的oxa-di-pi-甲烷光化学重排进行探索性研究，以期利用该反应作为构建存在于一些吡咯利西啶和吲哚利西啶生物碱结构中的环系统的方法。这些生物碱中有许多具有有效的抗生素和抗肿瘤特性。通过POWRE项目提供的机会将增强麦克卢尔教授的研究和领导潜力，以及她对本科生和研究生的教育指导。

This award from the Professional Opportunities for Women in Research and Education (POWRE) program for the research and educational activities of Professor Cynthia McClure of Montana State University is supported by funds provided by the National Institutes of Health through interagency transfer to NSF. The research enabled by the POWRE award aims at a new synthetic methodology for production of nitrogen heterocycles of biomedical significance. Professor McClure, an established researcher in organophosphorus chemistry, will undertake exploratory study of the oxa-di-pi-methane photochemical rearrangement of a series of aza-bicyclic systems, with a view to using the reaction as a method for constructing the ring system that is present in a number of pyrrolizidine and indolizidine alkaloid structures. Many of these alkaloids exhibit potent antibiotic and anti-tumor properties. The opportunity afforded through the POWRE program will enhance Professor McClure's research and leadership potential and her educational mentoring of undergraduate and graduate students.