NSF/Alfred P. Sloan Foundation Postdoctoral Research Fellowship in Molecular Evolution for FY 1998

DBI-9803890 Timothy S.Heuer这一行动为美国国家科学基金会/阿尔弗雷德·P·斯隆1998年分子进化博士后研究奖学金提供了资金。这些奖学金支持在有机体进化变化和适应的框架内，在分子水平上对生物模式和过程进行理论、比较、计算和/或实验分析的研究。这些研究还包括使用分子数据来解决更广泛的进化问题。每个研究金资助一项研究和培训计划，该计划将在一个赞助实验室进行。该研究金的研究和培训计划题为：结合生物重要小分子的蛋白质分子的选择：功能和结构蛋白质多样性和进化的研究。结合生物重要分子(如三磷酸腺苷、谷胱甘肽)的多肽将从1013个随机序列分子文库中挑选出来。功能多肽的丰富是通过结合目标配体并选择性地放大编码在体外翻译过程中共价连接的信使核糖核酸来实现的。经过多轮筛选和扩增，新出现的多肽将被表征，并与自然基序进行比较。

Abstract DBI-9803890 Timothy S. Heuer This action funds an NSF/Alfred P. Sloan Postdoctoral Research Fellowship in Molecular Evolution for 1998. These fellowships support studies involving the theoretical, comparative, computational, and/or experimental analyses of biological patterns and processes at the molecular level within the framework of organismic evolutionary change and adaptation. These studies also include the use of molecular data to address broader evolutionary questions. Each fellowship supports a research and training plan to be carried out in a sponsoring laboratory. The research and training plan for this fellowship is entitled selection of protein molecules that bind biologically important small molecules: a study of functional and structural protein diversity and evolution. Peptides that bind biologically important molecules (e.g. ATP, glutathione) will be selected from a library of 1013 random sequence molecules. Enrichment of functional peptides occurs by binding the target ligand and selectively amplifying the encoding mRNA, covalently attached during in vitro translation. After many rounds of selection and amplification, emergent peptides will be characterized and compared to natural motifs.