Purchase of a MALDI-TOF Mass Spectrometer

这份来自化学研究仪器和设施（CRIF）项目的合同将帮助特拉华大学化学和生物化学系获得基质辅助激光解吸电离飞行时间（MALDI-TOF）质谱仪。这种设备将加强若干领域的研究，包括：(1)共聚物表征，(2)寡核苷酸的二级结构分析，(3)蛋白质的键选择性光解，(4)亚阈值脉冲能量激光解吸/电离实验，(5)解吸/电离过程的分子动力学研究，(6)均聚物的解吸和阳离子化机理，(7)天然和合成聚合物的定量分析，(8)以冰为基质的IR-MALDI。质谱（MS）是一种用于探测内部结构细节和获得大量有机、生物有机和有机金属分子的分子组成的技术。它为化学家提供了表征化合物的最有力的工具之一。质谱分析能力的提高对化学领域的前沿研究至关重要。

This award from the Chemistry Research Instrumentation and Facilities (CRIF) Program will assist the Department of Chemistry and Biochemistry at the University of Delaware to acquire a matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometer. This equipment will enhance research in a number of areas including the following: (1) copolymer characterization, (2) secondary structural analysis of oligonucleotides, (3) bond-selective photodissociation in proteins, (4) laser desorption/ionization experiments using subthreshold pulse energies, (5) molecular dynamics studies of the desorption/ionization process, (6) homopolymer desorption and cationization mechanisms, (7) quantitative analysis of natural and synthetic polymers, and (8) IR-MALDI using ice as a matrix. Mass spectrometry (MS) is a technique used to probe intimate structural details and to obtain the molecular compositions of a vast array of organic, bioorganic, and organometallic molecules. It affords the chemist one of the most powerful tools available for the characterization of compounds. The acquisition of enhanced capability in mass spectrometry is essential for the prosecution of frontier research in many fields of chemistry.