GOALI: ICD Transvenous Lead Placement: An Active Bidomain Heart/Torso Simulation Study of Defibrillation Efficacy

9809132 Trayanova：这项研究的目的是开发一种新的纤颤心肌电活动模型，目的是优化除颤的导线放置。该模型在使用生物域方法方面是新颖的，它结合了细胞外和细胞内的离子电流以及活性膜的行为。该模型还考虑了构成心肌的肌肉纤维的方向和结构，研究人员发现，这对除颤电流诱导的电活动有重要影响。纤维结构取自新西兰的心肌纤维取向的详细地图。模型验证将在调查员实验室进行正在进行的实验工作的同时进行。这项研究是与一家名为Pacesetter，Inc.的公司合作进行的，该公司是设计和制造心律管理设备的行业领先者。***

9809132 Trayanova The objective of this research is the development of a novel model of the electrical activity of the fibrillating myocardium with the objective of optimizing lead placement for defibrillation. The model is novel in the use of a biodomain approach which incorporates both extra and intra- cellular ionic currents as well as the active membrane behavior. The model also takes into account the orientation and structure of the muscle fibers making up the myocardium, something which the investigator has discovered has an important bearing on the electrical activity induced by defibrillating currents. The fiber structure is to be taken from a detailed map of myocardial fiber orientation derived in New Zealand. Model validation is to be carried out with ongoing experimental work being done in the investigator's lab. This research is in collaboration with a company, Pacesetter, Inc., an industry leader in the design and manufacture of cardiac rhythm management devices. ***