Multilayer Membrane Structures for Protein Separations

提案编号：9811409提案类型：研究者发起首席研究员：Andrew Zydney联系：特拉华大学该资助通过化学和运输系统部界面、传输和分离项目的分离和纯化项目子元素授予。首席研究员是特拉华大学的Andrew Zydney博士。该项目涉及开发用于蛋白质分离的多层膜结构。它基于一个有趣的概念，即通过设计一种膜结构，顶层是相当开放的孔结构，底层是较小的孔结构，可以增强对蛋白质分离的选择性。本研究将考察浓度极化对物种渗透性、膜污染程度和可清洁性的影响。这些研究将证明使用多层膜进行蛋白质分离的可行性，为后续优化这些膜结构提供必要的框架，以实际纯化高价值蛋白质生产中遇到的特定蛋白质系统。

Abstract Proposal No: 9811409 Proposal Type: Investigator Initiated Principal Investigator: Andrew Zydney Affiliation: University of Delaware This grant is awarded through the Separations and Purification Program sub-element of the Interfacial, Transport and Separations Program of the Chemical and Transport Systems Division. The principal investigator is Dr. Andrew Zydney at the University of Delaware. The project involves the development multilayer membrane structures for protein separations. It is based on the interesting concept that selectivity to protein separations can be enhanced by designing a membrane structure with a top layer of fairly open pore structure and a bottom layer of smaller pore structure. The research will examine the effects of concentration polarization on species permeability, and the extent of membrane fouling and cleanability. The studies will demonstrate the feasibility of using multilayer membranes for protein separations, providing the necessary framework for the subsequent optimization of these membrane structures for the actual purification of specific protein systems encountered in the production of high value proteins.