Purchase of Integrated Fluorescence, Polarized Fluorescence and Brewster Angle Microscope/Langmuir Trough Instrumentation for Studies of Lipid-Protein Interactions at Interfaces

化学研究仪器和设施(CRIF)计划的这一奖项将使芝加哥大学化学系能够购买荧光和布鲁斯特角度显微镜/朗缪尔槽式组合仪器。这台设备将主要由初级教员Ka Yee C.Lee使用，他的研究重点是研究脂蛋白在界面上的相互作用；蛋白质与肺表面活性物质特定脂类之间的相互作用；以及膜脂在淀粉样β多肽聚集中的作用。李博士的研究涉及表面活性多肽与空气-水界面脂单分子层相互作用的表面化学研究，具有相当大的实用价值和基本意义。这些应用肯定会产生关于重要生物系统的有趣的新知识。此外，结果很可能与涉及早产儿和肺气肿的肺部疾病高度相关；因此，应该会对整个社会产生重大的有益影响。

This award from the Chemistry Research Instrumentation and Facilities (CRIF) Program will enable the Chemistry Department at the University of Chicago to purchase a combination fluorescence and Brewster angle microscope/Langmuir trough instrument. This equipment will be used primarily by junior faculty member Ka Yee C. Lee, whose research focuses on the study of lipid-protein interactions at interfaces; interactions between proteins and lung surfactant-specific lipids; and the role of membrane lipids in the aggregation of amyloid beta peptides. Dr. Lee's research, which involves surface chemical investigations of the interactions of surface-active peptides with lipid monolayers at the air-water interface, has considerable practical merit as well as fundamental significance. The applications are sure to yield interesting new knowledge regarding important biological systems. In addition, it is quite likely that the results will be highly relevant to lung diseases involving premature infants and emphysema; thus, there should be a significant beneficial effect on society at large.