Spherical Hydrophilic Polymers: Synthesis, Characterization and Applications

9901393Newkome本文描述的拟议研究是从先前的NSF资助中获得的结果的系统和合乎逻辑的扩展。这项建议的首要主题是研究经过内部和外部修饰的树枝状大分子的制备、结构方面和化学性质，这些树枝状大分子通过(1)组合技术来检查支化结构中的官能团协同作用，以及(2)结合金属配体结合位点来构建“更高阶”的树枝状网络和阵列。根据这一目标，设计和合成面向应用的树枝状大分子，从实用的树枝状构造块获得，可以通过定向或静态类型的反应方案制备，并基于充分记录的合成转化。组合技术将有助于构建具有不同构成功能的新型树枝状大分子家族。树枝状大分子的构建效率和组合技术的有用性将通过对催化活性(例如，磷酸酯水解)的材料分析来评估。使用内部改性的树枝状大分子来制备新材料也将通过树枝状组件和网络的模块化结构来例证。四面体单元在适当功能化时的自组装倾向以及迭代合成方法提供的结合LiCI的严格几何位置控制将有助于网络准备。有序阵列的连通性将采用金属络合物形成。项目目标包括：探索内部树枝状环境的潜在物理化学性质和应用。构建功能多样的树枝状大分子，用作可回收的、可水解的催化剂。构建能够与其他树枝状大分子形成连接的部分分隔的树枝状大分子。制备能够用于展示表面官能团活动性的功能衍生树枝状构建块和树枝状大分子。树枝状大河的组合构建，融合超支化和经典树枝状合成技术的最佳特征。%这项研究结合了对高度支化的、特别设计的大分子的相关化学和物理化学性质的研究，以及这些性质所固有的效用。这项研究的结果将为理解发生在“设计者”反应环境中的化学现象奠定基础。

9901393NewkomeThe proposed research described herein is a systematic and logical extension of the results obtained from prior NSF funding. The overriding theme of this proposal concerns the investigation of the preparation, structural aspects, and chemical propeties of dendrimers that have been internally and externally modified via (1) combinatorial techinques to examine functional group cooperativity within branced architectures and (2) the incorporation of metal ligand binding sites for the construction of "higher order" dendritic networks and arrays. Pursuant to this goal are the design and synthersis of application-oriented dendrimers accessed form utilitarian dendritic building blocks that can be prepared via directed- or statictical-type reaction shcemes and are based on well documented synthetic transformations. Combinatorial techinques will facilitate the construction of novel dendrimer families possessing constitutionally diverse fundtionality. Dendrimer construction efficiency and usefulness of the combinatorial techinique will be assessed by material analysis for catalytic activity(e.g., phosphate ester hydrolysis). Use of the internally modified dendrimers for the preparation of novel materials will also be exemplified by the modular construction of dendritic assemblies and networks. Network preparation will be facilitated by the propensity of tetrahedral units to self-assemble when appropriately functionalized and the strict geometric positional control of binding lici provided by the iterative synthetic method. Metal complex formation will be employed for the connectivity of the ordered arrays. Project goals include:Exploration of the potential physicochemical properties and applications of internal dendritic environments.Construction of functionally diverse dendrivers for use as recoverable, hydrolytic catalysts.Construction of dendrimers with compartmentalized moieties capable of forming connections with other dendrimers.Preparation of functionally derivatized dendritic building blocks and dendrivers that are capable of being used to demonstrate surface functional group mobility.Combinatorial construction of dendrivers to meld the best traits of hypebranched and classical dendritic synthetic techniques.%%%This research combines study of the chemistry associated with physicochemical properties of highly branched, specifically designed, macromolecule, with the attendant utility inherent in those properties. Results of this research will expand foundations for understanding of chemical phenomena occurring within "designer" reaction environments.