Integration of NMR Spectroscopy across the Chemistry and Biochemistry Undergraduate Curriculum

化学（12）核磁共振（NMR）是目前化学各个领域的研究人员可用的最有用和最通用的仪器技术之一。尽管它很重要，但在化学和生物化学课程中，核磁共振通常是不完整的，而且经常是偶然的。通常，核磁共振用于有机化学和仪器分析课程的结构解析。大多数学生毕业时都不知道核磁共振也可以用于研究动力学，热力学，平衡和构象，仅举几个应用。即使在拥有大型核磁共振研究设施的机构中，对核磁共振教学重视不足的主要原因是缺乏连贯的课程计划和广泛的教师专业知识。在这个项目中，我们通过在化学和生物化学本科课程中结合核磁共振波谱的理论和实践，以及对教师的培训来解决和克服这些缺陷。学生们早在大一就开始接触核磁共振，在以后的课程中会增加越来越复杂的经验。乌尔西纳学院正在进行的项目是我们项目的一个整体模型。在实施课程改革中使用的实验和材料来自不同的来源。首先，在其他机构成功的由DUE-NSF资助的项目开发的实验正在适应USP的学生受众，以反映他们对生化和生物医学问题的兴趣。第二，针对本科生的经过充分测试的实验正在从文献中改编，最后，教师们正在开发针对特定问题的新实验。此外，现代高分辨率核磁共振光谱仪的可用性使所有化学相关专业（如化学，生物化学，生物学，药理学和毒理学）的学生能够进行本科研究，这在我们学校以前是不可能的。由于几乎所有USP的学生都学了整整一年的化学，70%的学生学了三年，所以大量的年轻科学家毕业时将掌握多核、多脉冲和二维核磁共振技术，这将为他们未来的职业生涯提供重要的优势。该项目还评估和传播来自本科生核磁共振项目的结果。除了传统的方法，如在同行评议的期刊和地方和国家会议上发表新的实验室实验和本科生研究结果，我们还使用基于互联网的工具进行项目评估和传播。这些工具还为学生和教师传播材料提供了方便的途径，并允许在学生反馈的指导下进行快速评估和项目调整。

Chemistry (12) Nuclear magnetic resonance (NMR) is one of the most useful and versatile instrumental techniques currently available to researchers in all areas of chemistry. Despite its importance, NMR is typically covered incompletely, and oftentimes haphazardly, across the chemistry and biochemistry curricula. Typically, NMR is used for structural elucidation in organic chemistry and instrumental analysis courses. Most students graduate without knowing that NMR can also be used to study kinetics, thermodynamics, equilibria, and conformation, just to name a few applications. The main reasons for this weak emphasis on NMR instruction, even in institutions with large NMR research facilities, are the lack of a cohesive curricula plan and lack of broad faculty expertise. In this project, we address and overcome these deficiencies through the incorporation of the theory and practice of NMR spectroscopy across the chemistry and biochemistry undergraduate curricula, and training of the faculty. Students are introduced to NMR as early as their freshman year, with increasingly sophisticated experiences added in later courses. The program underway at Ursinus College is serving as an overall model for our program. The experiments and materials used in the implementation of the curricula changes derive from different sources. First, experiments developed by successful DUE-NSF funded programs at other institutions are being adapted to the student audience at USP in order to reflect their interest in biochemical and biomedical problems. Second, well-tested experiments aimed at undergraduates are being adapted from the literature, and, finally, faculty are developing novel experiments targeting specific problems. Furthermore, the availability of a modern high resolution NMR spectrometer allows students in all chemistry-related majors (e.g., chemistry, biochemistry, biology, pharmacology & toxicology) to perform undergraduate research at levels previously impossible at our institution. Since virtually all students at USP take one full year of chemistry, and 70% take three years, a very large number of young scientists will graduate with knowledge of multinuclear, multiple-pulse, and 2D NMR techniques, which will give them an important edge in their future careers.The project also is evaluating and disseminating the results from the undergraduate NMR program. In addition to conventional methods, such as presentation and publication of novel laboratory experiments and results from undergraduate research in peer-reviewed journals and at local and national meetings, we are using internet-based tools for program evaluation and dissemination. These tools also provide convenient routes for dissemination of materials to students and faculty, and they allow for rapid evaluation and program adaptation guided by student feedback.