Integration of FT-NMR Spectroscopy Throughout the Chemistry Curriculum

傅里叶变换对核磁共振的应用使化学研究发生了革命性的变化。傅立叶变换核磁共振光谱学在本科生的化学课程中扮演着重要的角色。在这个项目中，一个旧的连续波核磁共振已经被转换成现代的多核Anasazi EFT-60 FT-核磁共振，在实现获得FT-核磁共振的复杂性和速度的目标中发挥了关键作用。事实证明，对于小型本科学校来说，这种升级是一种维护成本低、成本效益高的替代昂贵的高场核磁共振光谱仪。长期目标是在整个课程中整合傅里叶变换核磁共振光谱学，以培养在现代傅立叶变换核磁共振光谱学的技术和科学方面受过教育的研究生。从大一的课程(普通化学、专职卫生专业人员的普通化学以及化学、环境与健康)开始，学生通过一系列需要“动手”参与的实验，从理论和经验上向学生介绍FT-核磁共振波谱学。随着学生完成化学课程(有机、仪器分析、生物化学、高级无机化学和物理化学)，他们进行实验，培养制备样品和运行常规1H和13C核磁共振谱的技术能力。到毕业时，化学专业通过彻底的、精心设计的实验来体验2D和异核技术，这些实验展示了现代FT-核磁共振光谱学的广度和应用。这些实验是以一种有节制的增量方式介绍的，并改编自最近的文献(主要是J.化学教育)。非理科专业的学生学习傅立叶变换核磁共振光谱学，以便他们能够尊重和理解现代化学中精密仪器的必要性。使用外部(咨询委员会)和内部评价的持续评估提供反馈和指导，说明该项目的成功是对课程的重大改进。

Chemistry (12) Fourier transform applications to NMR have revolutionized chemical inquiry. FT-NMR spectroscopy plays an essential role in the undergraduate chemistry curriculum. In this project, an older continuous-wave NMR which has been converted to a modern multinuclear Anasazi EFT-60 FT- NMR plays a key role in achieving the goal of obtaining the sophistication and speed of FT-NMR. Such upgrades have proven to be a low-maintenance and cost-effective alternative to expensive high-field NMR spectrometers for small undergraduate schools. The long-term goal is the integration FT-NMR spectroscopy throughout the curriculum to produce graduates educated in the technical and scientific aspects of modern FT-NMR spectroscopy. Beginning with the freshman courses (General Chemistry, General Chemistry for Allied Health Professions, and Chemistry , Environment and Health) students are introduced to FT-NMR spectroscopy both theoretically and experientially through a series of experiments designed to require "hands-on" involvement. As students progress through the chemistry curriculum (Organic, Instrumental Analysis, Biochemistry, Advanced Inorganic and Physical Chemistry) they perform experiments that develop technical competency in preparing samples and running routine 1H and 13C NMR spectra. By graduation, the chemistry major experiences 2D- and heteronuclear techniques by means of thorough, well-planned experiments that demonstrate the breadth and applications of modern FT-NMR spectroscopy. These experiments are introduced in a measured incremental fashion and are adapted from recent literature (primarily the J. Chemical Education). The non-science major is introduced to FT-NMR spectroscopy so they can respect and appreciate the necessity of sophisticated instrumentation in modern chemistry. Continuous assessments using both external (Advisory Board) and internal evaluations provide feedback and guidance on the success of the project as a significant curricular enhancement.